April 2017, Volume 59 Issue 4, Pages 229–287.
Cover Caption: Tonoplast targeting of V-ATPase
Similar to the transportation network in a city, the dynamic trafficking of membrane proteins is crucial for a cell to function properly. In this issue, Feng et al. (230-233) demonstrate that tonoplast associated V-ATPase is transported through a Rab5-mediated but Rab7- independent pathway, suggesting the presence of a non-conventional vacuolar trafficking route in plant cells.