Abstract:

Twelve steroids, including eight ergostane-type sterols and four mono-glucosides of ergostane-type sterols, were isolated from the ethyl acetate soluble fraction of the fungus Pleurotus ostreatus (Jacq.:Fr.) Kummer. A new compound 3-O-β-D-glucopyranosyl-22 E, 24R-ergosta-7, 22-diene-5α, 6β, 9α-triol, was structurally elucidated by spectroscopic and chemical methods. The eleven known compounds were 22E, 24R-ergosta-7, 22-diene-3β, 5α, 6β, 9α-tetraol; 3-O--D-glucopyranosyl-22E, 24R-ergosta-7, 22-diene-5α, 6β-diol; 22E, 24R-ergosta-7, 22-diene-3β, 5α, 6β-triol; 22E, 24R-ergosta-5, 7, 22-trien-3β-ol 3-O-β-D-glucopyranoside; ergosterol; 22E, 24R-ergosta-7, 22-dien-3β-ol 3-O-β-D-glucopyranoside; 22E, 24R-ergosta-7, 22-diene-3β-ol; 22E, 24R-ergosta-4, 6, 8, 22-tetraen-3-one; 22E, 24R-ergosta-7, 22-diene-3β, 5α, 6α-triol; ergosterol peroxide; 22E, 24R-ergosta-7, 22_diene-3β, 5α-diol-6-one.

北风菌中的甾体和甾体苷类化合物
占扎君 王 莹 杨升平 岳建民

（中国科学院上海生命科学研究院上海药物研究所新药研究国家重点实验室，上海200031）

摘要：从口蘑科真菌北风菌(Pleurotus ostreatus (Jacq．：Fr．)Kummer)的乙酸乙酯部分分离鉴定了12个甾体类化合物，其中包括8个麦角甾醇类甾体及4个甾体苷。利用现代波谱技术及化学方法，鉴定了一个新化合物3-O-β-D-glucopyranosyl-22E, 24R-ergosta-7, 22-diene-5a, 613, 9α-triolo 其余11个已知化合物分别为22E,24R-ergosta-7, 22-di-ene-3β, 5a, 6β3, 9α-tetraol, 3-O-β-D-glueopyranosyl-22E, 24R-ergosta-7, 22-diene-5α, 6β-diol、22E, 24R-ergosta-7, 22-di-ene-3β, 5α, 6β-triol, 22E, 24R-ergosta-5, 7, 22-tfien-3β-ol 3-O-β-D-glueopyranoside, ergosterol, 22E, 24R-ergosta-7, 22-dien-3β-ol 3-O-β -D-glueopyranoside, 22E, 24R-ergosta-7, 22-diene-3β-ol、 22E, 24R-ergosta-4, 6, 8, 22-tetraen-3-one、22E, 24R-ergosta-7, 22-diene-313, 5ct, 6a-tfiol, ergosterol peroxide 和 22E, 24R-ergosta-7, 22-diene-3β, 5α-diol-6-oneo (关键词：北风菌,口蘑科,甾体,甾体苷；-O-β-D-glueopyranosy1-22E, 24R-ergosta-7,22-diene-5a,6β,9a-triol

通讯作者。E-mail: jmyue @ mail.shcnc.ac.cn。