Abstract: Crystal V, VI and VII were isolated from the seeds of Goniothalamus howii Merr. Et Chun. Based on the analysis of IR, 1H-NMR, 13C-NMR, MS and spectral analysis of their derivatives, they were identified as a new type of annonaceous acetogenins—seco-biste-trahydrofuran annonaceous acetogenins. V and VI were named as howiicin D and howiicin E, respectively. VII is a mixture of two compounds, named howiicins F and C, which have the same plane structure.

Key words: Goniothalamus howii, Seco-bistetrahydrofuran type annonaceous acetogenins, Howiicins D, Howiicins E, Howiicins F, Howiicins G