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Professor David Twell

Director of Electron Microscope Laboratory
University of Leicester
Adrian Building, Room 313
University Road
Leicester
LE1 7RH, UK
Tel: +44-116 252 2281 ; Fax: +44-116 252 2791
E-mail: twe@leicester.ac.uk
http://www2.le.ac.uk/departments/biology/people/twell
Area of expertise: Male gametophyte development; cell polarity and asymmetric division, gametophytic genetics and genomics; gene regulatory networks; germline cell specification and cell cycle control.
Co-editor until: Oct. 31, 2011
   
Selected Publications:  
   
  • Brownfield L, Twell D (2009) A dynamic DUO of regulatory proteins coordinates gamete specification and germ cell mitosis in the angiosperm male germline. Plant Signal. Behav. 4, 1-4.
  • Erilova A, Brownfield L, Exner V, Rosa M, Twell D, Mittelsten Scheid O, Hennig L, K?hler C (2009) Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis. PLoS Genet 5, e1000663.
  • Brownfield L, Hafidh S, Durbarry A, Khatab H, Sidorova A, Doerner P, Twell D (2009) Arabidopsis DUO POLLEN 3 is a key regulator of male germline development and embryogenesis. Plant Cell 21, 1940-1956.  
  • Gibalová A, Renák D, Matczuk K, Dupláková N, Cháb D, Twell D, Honys D (2009) AtbZIP34 is required for Arabidopsis pollen wall patterning and the control of several metabolic pathways in developing pollen. Plant Mol. Biol.  70, 581-601.
  • Chen Z, Hafidh S, Poh SH, Twell D, Berger F (2009) Hyperproliferation caused by loss of Retinoblastoma prevents cell fate establishment during Arabidopsis male gametogenesis. Proc. Natl. Acad. Sci. USA 106, 7257-62.
  • Brownfield L, Hafidh S, Borg M, Sidorova A, Mori T, Twell D (2009) A plant germline-specific integrator of sperm specification and cell cycle progression. PLoS Genet. 5, e1000430.
  • Borg M, Brownfield L, Twell D (2009) Male gametophyte development: A molecular perspective. J. Exp. Bot. 60, 1465-1478.
  • Twell D (2009) Male Gametophyte Development. In E. C. Chong & M. R. Davies (Eds.) Plant Developmental Biology-Biotechnological Perspectives . Springer, Germany. (in press)
  • Kim HJ, Oh SA, Brownfield L, Hong SH, Ryu H, Hwang I, Twell D, Nam HG (2008) Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors. Nature 455, 1134-1137.
  • Oh SA, Bourdon V, Das 'Pal M, Dickinson H, Twell D (2008) Arabidopsis kinesins HINKEL and TETRASPORE act redundantly to control cell plate expansion during cytokinesis in the male gametophyte. Mol. Plant 1, 794-799.
  • Töller A, Brownfield L, Neu C, Twell D, Schulze-Lefert P (2008) Dual function of Arabidopsis glucan synthase-like genes GSL8 and GSL10 in male gametophyte development and plant growth. Plant J. 54, 911-923.
  • Quan L, Xiao R, Li W, Oh SA, Kong H, Ambrose JC, Malcos JL, Cyr R, Twell D, Ma H (2008) Functional divergence of the duplicated AtKIN14a and AtKIN14b genes: critical roles in Arabidopsis meiosis and gametophyte development. Plant J. 53, 1013-1026.
  • Verelst W, Twell D, de Folter S, Immink R, Saedler H, Münster T (2007) MADS-complexes regulate transcriptome dynamics during pollen maturation. Genome Biol. 8, R249.
  • Andersen SU, Algreen-Petersen RG, Hoedl M, Jurkiewicz A, Cvitanich C, Braunschweig U, Schauser L, Oh SA, Twell D, Jensen EO (2007) The conserved cysteine-rich domain of a tesmin/TSO1-like protein binds zinc in vitro and TSO1 is required for both male and female fertility in Arabidopsis thaliana. J. Exp. Bot. 58, 3657-3670.
  • Honys D, Oh SA, Renak D, Donders M, Solcova B, Johnson JA, Boudova R, Twell D (2006) Identification of microspore-active promoters that allow targeted manipulation of gene expression at early stages of microgametogenesis in Arabidopsis. BMC Plant Biol. 6, 31.
  • Novak JP, Kim SY, Xu J, Modlich O, Volsky DJ, Honys D, Slonczewski JL, Bell DA, Blattner FR, Blumwald E, Boerma M, Cosio M, Gatalica Z, Hajduch M, Hidalgo J, McInnes RR, Miller MC 3rd, Penkowa M, Rolph MS, Sottosanto J, St-Arnaud R, Szego MJ, Twell D, Wang C (2006) Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution. Biol. Direct 1, 27.
  • Bock KW, Honys D, Ward JM, Padmanaban S, Nawrocki EP, Hirschi KD, Twell D, Sze H (2006) Integrating membrane transport with male gametophyte development and function through transcriptomics. Plant Physiol. 140, 1151-1168.
  • Oh SA, Johnson JA, Smertenko A, Rahman D, Park S-K, Hussey PJ, Twell D (2006) A divergent cellular role for the FUSED kinase family in the plant-specific cytokinetic phragmoplast. Curr. Biol. 15, 2107-2111.
  • Honys D, Renak D, Twell D (2006) Male Gametophyte Development and Function. In Teixera da Silva JA (Ed.), Floriculture, Ornamental and Plant Biotechnology: Advances and Topical Issues (1st Edition). Global Science Books, London, UK. pp. 76-87.
  • Twell D, Oh SA, Honys D (2006) Pollen development, a genetic and transcriptomic view. In Malho R (ed.) The Pollen Tube: A Cellular and Molecular Perspective . Plant Cell Monographs Volume 3. Springer-Verlag, Berlin. pp.15-45.
  • Baldwin A, Wardle A, Patel R, Dudley P, Park SK, Twell D, Inoue K, Jarvis P (2005) A molecular-genetic study of the Arabidopsis Toc75 gene family. Plant Physiol. 138, 715-733.
  • Rotman N, Durbarry A, Wardle A, Yang W-C, Chaboud A, Faure JE, Berger F, Twell D (2005) A novel class of MYB factors controls sperm cell formation in plants. Curr. Biol. 15, 244-248.
  • Durbarry A, Vizir I, Twell D (2005) Male germ line development in Arabidopsis: duo pollen mutants reveal gametophytic regulators of generative cell cycle progression. Plant Physiol. 137, 297-307.
  • Combe JP, Petracek ME, van Eldik G, Meulewaeter F, Twell D (2005) Translation initiation factors eIF4E and eIFiso4E are required for polysome formation and regulate plant growth in tobacco. Plant Mol. Biol. 57, 749-760.
  • Hrubá P, Honys D, Twell D, Capková V, Tupy J (2005) Expression of beta-galactosidase and beta-xylosidase genes during microspore and pollen development. Planta 220, 931-940.
  • Kovacheva S, Bedard J, Patel R, Dudley P, Twell D, Rios G, Koncz C, Jarvis P (2005) In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import. Plant J. 41, 412-428.