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Assistant Professor Tomohiko Tsuge

Molecular Biology Laboratory
Institute for Chemical Research, Kyoto University
Gokasho Uji, KYOTO 611-0011, Japan
Tel: +81-774-38-3263; Fax: +81-774-38-3259
E-mail: tsuge@scl.kyoto-u.ac.jp
http://www.kuicr.kyoto-u.ac.jp/icr-bin/KUICR_info_e.pl?user=tsuge+tomohiko
http://molbio.kuicr.kyoto-u.ac.jp/mbl/index_e.html
Area of expertise: Light signaling pathways; protein degradation; photomorphogenesis; leaf development.
Co-editor until: October 31, 2011
   
Selected Publications:  
   
  • Taniguchi YY, Taniguchi M, Tsuge T, Oka A, Aoyama T (2010) Involvement of Arabidopsis thaliana phospholipase Dζ2 in root hydrotropism through the suppression of root gravitropism. Planta 231, 491-497.
  • Oka A, Tsuge T (2008) Chapter3 Regulation of ploidy - aiming to create bigger and stronger plants.Getting the forest back. Kaiseisha Ohtsu 35-44 .
  • Liu J, Zhang Y, Qin G, Tsuge T, Sakaguchi N, Luo G, Sun K, Shi D, Aki S, Zheng N, Aoyama T, Oka A, Yang W, Umeda M, Xie Q, Gu H, Qu LJ (2008) Targeted degradation of ICK4/KRP6 by the RING type E3 ligases RHF1a and RHF2a is essential for mitotic cell cycle progression during Arabidopsis gametogenesis. Plant Cell 20, 1589-1600.
  • Li LC, Qin GJ, Tsuge T, Hou XH, Ding MY, Aoyama T, Oka A, Chen Z, Gu H, Zhao Y, Qu LJ (2008) SPOROCYTELESS modulates YUCCA expression to regulate the development of lateral organs in Arabidopsis. New Phytol. 179, 751-764.
  • Kusano H, Testerink C, Vermeer JE, Tsuge T, Shimada H, Oka A, Munnik T, Aoyama T (2008) The Arabidopsis phosphatidylinositol phosphate 5-kinase PIP5K3 is a key regulator of root hair tip growth. Plant Cell 20, 367-380.
  • Menon S, Tsuge T, Dohmae N, Takio K, Wei N (2008) Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. BMC Biochem. 9, 1.
  • Li L, Hou X, Tsuge T, Ding M, Aoyama T, Oka A, Gu H, Zhao Y, Qu LJ (2008) The possible action mechanisms of indole-3-acetic acid methyl ester in Arabidopsis. Plant Cell Rep. 27, 575-584.
  • Pick E, Lau OS, Tsuge T, Menon S, Tong Y, Dohmae N, Plafker SM, Deng XW, Wei N (2007) Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. Mol. Cell Biol. 27, 4708-4719.
  • Katou S, Kuroda K, Seo S, Yanagawa Y, Tsuge T, Yamazaki M, Miyao A, Hirochika H, Ohashi Y (2007) A calmodulin-binding mitogen-activated protein kinase phosphatase is induced by wounding and regulates the activities of stress-related mitogen-activated protein kinases in rice. Plant Cell Physiol. 48, 332-344.
  • Taniguchi M, Sasaki N, Tsuge T, Aoyama T, Oka A (2007) ARR1 directly activates cytokinin response genes that encode proteins with diverse regulatory functions. Plant Cell Physiol. 48, 263-277.
  • Tsuge T (2006) The ubiquitin regulation in photomorphogenesis. (in Japanese) Tanpakushitu Kakusan Koso. Kyoritsu, Tokyo. Vol.51, No.10 Suppl. 1352-1357.
  • Tsuge T(2006) The unique auxin perception by SCF-mediated pathways. (in Japanese) Tanpakushitu Kakusan Koso. Kyoritsu, Tokyo. Vol.51, No.10 Suppl. 1358.
  • Tsuge T, Tsukaya H (2006) Shoot - The architecture of plant module. (in Japanese) Plantmimetics - learning from plants. NTS, Tokyo. 4-10.
  • Imai KK, Ohashi Y, Tsuge T, Yoshizumi T, Matsui M, Oka A, Aoyama T (2006) The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication. Plant Cell 18, 382-396.
  • Tsuge T, Oka (2005) A "Latest Topics" Will the research in plant light signaling contribute to the cure of cancer? ?The frontier research of COP9 Signalosome. (in Japanese) Chemistry. Kagakudojin, Kyoto. Vol.60, 72-73.
  • Tsuge T (2004) COP9 Signalosome is involved in morphogenesis and responses to environmental stimuli. (in Japanese) Crosstalk between adaptive responses to environmental stimuli and morphogenesis in plants. Springer-Verlag, Tokyo. 163-169.
  • Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, Deng XW (2003) Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell 15, 719-731.
  • Yang X, Menon S, Lykke-Andersen K, Tsuge T, Di Xiao, Wang X, Rodriguez-Suarez RJ, Zhang H, Wei N (2002) The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Curr. Biol. 12, 667-672.
  • Kim GT, Shoda K, Tsuge T, Cho KH, Uchimiya H, Yokoyama R, Nishitani K, Tsukaya H (2002) The ANGUSTIFOLIA gene of Arabidopsis, a plant CtBP gene, regulates leaf-cell expansion, the arrangement of cortical microtubules in leaf cells and expression of a gene involved in cell-wall formation. EMBO J. 21, 1267-1279.
  • Tsukaya H, Tsuge T (2001) Morphological adaptation of inflorecences in plants that develop at low temperatures in early spring : the convergent evolution of "downy plants". Plant Biol. 3, 536-543.
  • Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001) Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292, 1382-1385.
  • Tsuge T, Matsui M, Wei N (2001) The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. J. Mol. Biol. 305, 1-9.
  • Tsuge T, Inagaki N, Yoshizumi T, Shimada H, Kawamoto T, Matsuki R, Yamamoto N, Matsui M (2001) Phytochrome-mediated control of COP1 gene expression in rice plants. Mol. Genet. Genomics 265, 43-50.
  • Serino G, Tsuge T, Kwok S, Matsui M, Wei N, Deng XW (1999) Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Plant Cell 11, 1967-1980.
  • Karniol B, Yahalom A, Kwok S, Tsuge T, Matsui M, Deng XW, Chamovitz DA (1998) The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. FEBS Lett. 439, 173-179.
  • Kwok SF, Solano R, Tsuge T, Chamovitz DA, Ecker JR, Matsui M, Deng XW (1998) Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Plant Cell 10, 1779-1790.
  • Shibata D, Seki M, Mitsukawa N, Hayashida N, Ito T, Taji T, Tsuge T, Matsui M, Anai T, Liu YG, Whittier RF, Shinozaki K (1998) Establishment of framework P1 clones for map-based cloning and genome sequencing: direct RFLP mapping of large clones. Gene 225, 31-38. 
  • Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (1998) The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 8, 919-922.
  • Anai T, Kono N, Takai R, Tsuge T, Matsui M, Kosemura S, Yamamura S, Hasegawa K (1998) Nucleotide sequence of oat (Avena sativa L.) cDNA encoding an auxin-binding protein (ABP1). DNA Seq. 8, 235-239.
  • Anai T, Miyata M, Kosemura S, Yamamura S, Tsuge T, Matsui M, Uchida H, Hasegawa K (1997) Comparison of abp1 primary sequences from monocotyledonous and dicotyledonous species. J. Plant Physiol. 151, 446-449.
  • Tsuge T, Tsukaya H, Uchimiya H (1996) Two independent and polarized processes of cell elongation regulate leaf blade expansion in Arabidopsis thaliana (L.) Heynh. Development 122, 1589-1600.
  • Tsukaya H, Tsuge T, Kim GT, Uchimiya H (1995) Genetic analysis of cell-expansion processes in leaves of Arabidopsis thaliana. Plant Morph. 7, 11-17.
  • Tsukaya H, Tsuge T, Uchimiya H (1994) The cotyledon: A superior system for studies of leaf development. Planta 195, 309-312.
  • Kidou S, Umeda M, Tsuge T, Kato A, Uchimiya H (1994) Isolation and characterization of a rice cDNA similar to the S-phase-specific cyc07 gene. Plant Mol. Biol. 24, 545-547.
  • Kidou S, Anai T, Umeda M, Aotsuka S, Tsuge T, Kato A, Uchimiya H (1993) Molecular structure of ras-related small GTP-binding protein genes of rice plants and GTPase activities of gene products in Escherichia coli. FEBS Lett. 332, 282-286.