Special Issue: Receptor-Like Kinases   

December 2013, Volume 55 Issue 12, Pages 1181每1286.

Cover Caption: Receptor-Like Kinases
About the cover: Genetic studies reveal the essential role of BAK1 in the BRI1-mediated BR signaling pathway. Structure analyses reported recently by two independent groups suggest that the extracellular domain of BAK1 may bind directly to BR and activate the BRI1 signalling. For details, please read the article written by He et al. (pp. 1264每1270).


Journal of Integrative Plant Biology 2013 55(12): 1182每1183
Published Online: December 6, 2013
DOI: 10.1111/jipb.12134
Abstract (Browse 652)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
Receptor-Like Kinases: Key Regulators of Plant Development and Defense  
Author: Jia Li and Frans E. Tax
Journal of Integrative Plant Biology 2013 55(12): 1184每1187
Published Online: December 6, 2013
DOI: 10.1111/jipb.12129
Abstract (Browse 996)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
          Invited Expert Reviews
Big Roles of Small Kinases: The Complex Functions of Receptor-Like Cytoplasmic Kinases in Plant Immunity and Development  
Author: Wenwei Lin, Xiyu Ma, Libo Shan and Ping He
Journal of Integrative Plant Biology 2013 55(12): 1188每1197
Published Online: September 18, 2013
DOI: 10.1111/jipb.12071
Plants have evolved a large number of receptor-like cytoplasmic kinases (RLCKs) that often functionally and physically associate with receptor-like kinases (RLKs) to modulate plant growth, development and immune responses. Without any apparent extracellular domain, RLCKs relay intracellular signaling often via RLK complex-mediated transphosphorylation events. Recent advances have suggested essential roles of diverse RLCKs in concert with RLKs in regulating various cellular and physiological responses. We summarize here the complex roles of RLCKs in mediating plant immune responses and growth regulation, and discuss specific and overlapping functions of RLCKs in transducing diverse signaling pathways.

Lin W, Ma X, Shan L, He P (2013) Big roles of small kinases: The complex functions of receptor坼like cytoplasmic kinases in plant immunity and development. J. Integr. Plant Biol. 55(12), 1188–1197.

Abstract (Browse 1286)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
Ligand Perception, Activation, and Early Signaling of Plant Steroid Receptor Brassinosteroid Insensitive 1  
Author: Jianjun Jiang, Chi Zhang and Xuelu Wang
Journal of Integrative Plant Biology 2013 55(12): 1198每1211
Published Online: September 9, 2013
DOI: 10.1111/jipb.12081
Leucine-rich repeat receptor-like kinases (LRR-RLKs) belong to a large group of cell surface proteins involved in many aspects of plant development and environmental responses in both monocots and dicots. Brassinosteroid insensitive 1 (BRI1), a member of the LRR X subfamily, was first identified through several forward genetic screenings for mutants insensitive to brassinosteroids (BRs), which are a class of plant-specific steroid hormones. Since its identification, BRI1 and its homologs had been proved as receptors perceiving BRs and initiating BR signaling. The co-receptor BRI1-associated kinase 1 and its homologs, and other BRI1 interacting proteins such as its inhibitor BRI1 kinase inhibitor 1 (BKI1) were identified by genetic and biochemical approaches. The detailed mechanisms of BR perception by BRI1 and the activation of BRI1 receptor complex have also been elucidated. Moreover, several mechanisms for termination of the activated BRI1 signaling were also discovered. In this review, we will focus on the recent advances on the mechanism of BRI1 phosphorylation and activation, the regulation of its receptor complex, the structure basis of BRI1 ectodomain and BR recognition, its direct substrates, and the termination of the activated BRI1 receptor complex.

Jiang J, Zhang C, Wang X (2013) Ligand perception, activation, and early signaling of plant steroid receptor brassinosteroid insensitive 1. J. Integr. Plant Biol. 55(12), 1198–1211.

Abstract (Browse 1272)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
Structure-function Aspects of Extracellular Leucine-rich Repeat-containing Cell Surface Receptors in Plants  
Author: Zhao Zhang and Bart P.H.J. Thomma
Journal of Integrative Plant Biology 2013 55(12): 1212每1223
Published Online: September 18, 2013
DOI: 10.1111/jipb.12080
Plants exploit several types of cell surface receptors for perception of extracellular signals, of which the extracellular leucine-rich repeat (eLRR)-containing receptors form the major class. Although the function of most plant eLRR receptors remains unclear, an increasing number of these receptors are shown to play roles in innate immunity and a wide variety of developmental processes. Recent efforts using domain swaps, gene shuffling analyses, site-directed mutagenesis, interaction studies, and crystallographic analyses resulted in the current knowledge on ligand binding and the mechanism of activation of plant eLRR receptors. This review provides an overview of eLRR receptor research, specifically summarizing the recent understanding of interactions among plant eLRR receptors, their co-receptors and corresponding ligands. The functions of distinct eLRR receptor domains, and their role in structure, ligand perception and multimeric complex formation are discussed.

Zhang Z, Thomma BPHJ (2013) Structure坼function aspects of extracellular leucine坼rich repeat坼containing cell surface receptors in plants. J. Integr. Plant Biol. 55(12), 1212–1223.

Abstract (Browse 1211)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
Notes from the Underground: Receptor-Like Kinases in Arabidopsis Root Development  
Author: Michael P. Wierzba and Frans E. Tax
Journal of Integrative Plant Biology 2013 55(12): 1224每1237
Published Online: October 10, 2013
DOI: 10.1111/jipb.12088
During plant development, the frequency and context of cell division must be controlled, and cells must differentiate properly to perform their mature functions. In addition, stem cell niches need to be maintained as a reservoir for new cells. All of these processes require intercellular signaling, whether it is a cell relaying its position to other cells, or more mature cells signaling to the stem cell niche to regulate the rate of growth. Receptor-like kinases have emerged as a major component in these diverse roles, especially within the Arabidopsis root. In this review, the functions of receptor-like kinase signaling in regulating Arabidopsis root development will be examined in the areas of root apical meristem maintenance, regulation of epidermal cell fate, lateral root development and vascular differentiation.

Wierzba MP, Tax FE (2013) Notes from the underground: Receptor坼like kinases in Arabidopsis root development. J. Integr. Plant Biol. 55(12), 1224–1237.

Abstract (Browse 995)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
Diverse Roles of ERECTA Family Genes in Plant Development  
Author: Elena D. Shpak
Journal of Integrative Plant Biology 2013 55(12): 1238每1250
Published Online: October 30, 2013
DOI: 10.1111/jipb.12108
Multiple receptor-like kinases (RLKs) enable intercellular communication that coordinates growth and development of plant tissues. ERECTA family receptors (ERfs) are an ancient family of leucine-rich repeat RLKs that in Arabidopsis consists of three genes: ERECTA, ERL1, and ERL2. ERfs sense secreted cysteine-rich peptides from the EPF/EPFL family and transmit the signal through a MAP kinase cascade. This review discusses the functions of ERfs in stomata development, in regulation of longitudinal growth of aboveground organs, during reproductive development, and in the shoot apical meristem. In addition the role of ERECTA in plant responses to biotic and abiotic factors is examined.

Shpak ED (2013) Diverse roles of ERECTA family genes in plant development. J. Integr. Plant Biol. 55(12), 1238–1250.

Abstract (Browse 921)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
Letting Go is Never Easy: Abscission and Receptor-Like Protein Kinases  
Author: Chad E. Niederhuth, Sung Ki Cho, Kati Seitz and John C. Walker
Journal of Integrative Plant Biology 2013 55(12): 1251每1263
Published Online: December 6, 2013
DOI: 10.1111/jipb.12116

Abscission is the process by which plants discard organs in response to environmental cues/stressors, or as part of their normal development. Abscission has been studied throughout the history of the plant sciences and in numerous species. Although long studied at the anatomical and physiological levels, abscission has only been elucidated at the molecular and genetic levels within the last two decades, primarily with the use of the model plant Arabidopsis thaliana. This has led to the discovery of numerous genes involved at all steps of abscission, including key pathways involving receptor-like protein kinases (RLKs). This review covers the current knowledge of abscission research, highlighting the role of RLKs.

Niederhuth CE, Cho SK, Seitz K, Walker JC (2013) Letting go is never easy: Abscission and receptor坼like protein kinases. J. Integr. Plant Biol. 55(12), 1251–1263.

Abstract (Browse 701)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
BAK1 Directly Regulates Brassinosteroid Perception and BRI1 Activation  
Author: Kai He, Shengbao Xu and Jia Li
Journal of Integrative Plant Biology 2013 55(12): 1264每1270
Published Online: December 6, 2013
DOI: 10.1111/jipb.12122

Plants utilize plasma membrane-localized receptor-like kinases (RLKs) to sense extracellular signals to coordinate growth, development, and innate immune responses. BAK1 regulates multiple signaling pathways acting as a co-receptor of several distinct ligand-binding RLKs. It has been debated whether BAK1 serves as an essential regulatory component or only a signal amplifier without pathway specificity. This issue has been clarified recently. Genetic and structural analyses indicated that BAK1 and its homologs play indispensible roles in mediating brassinosteroid (BR) signaling pathway by directly perceiving the ligand BR and activating the receptor of BR, BRI1. The mechanism revealed by these studies now serves as a paradigm for how a pair of RLKs can function together in ligand binding and subsequent initiation of signaling.

He K, Xu S, Li J (2013) BAK1 directly regulates brassinosteroid perception and BRI1 activation. J. Integr. Plant Biol. 55(12),1264–1270.

Abstract (Browse 768)  |  References  |  Full Text HTML  |  Full Text PDF  |  Cited By       
Receptor-Like Kinases in Plant Innate Immunity  
Author: Ying Wu and Jian-Min Zhou
Journal of Integrative Plant Biology 2013 55(12): 1271每1286
Published Online: December 6, 2013
DOI: 10.1111/jipb.12123

Plants employ a highly effective surveillance system to detect potential pathogens, which is critical for the success of land plants in an environment surrounded by numerous microbes. Recent efforts have led to the identification of a number of immune receptors and components of immune receptor complexes. It is now clear that receptor-like kinases (RLKs) and receptor-like proteins (RLPs) are key pattern-recognition receptors (PRRs) for microbe- and plant-derived molecular patterns that are associated with pathogen invasion. RLKs and RLPs involved in immune signaling belong to large gene families in plants and have undergone lineage specific expansion. Molecular evolution and population studies on phytopathogenic molecular signatures and their receptors have provided crucial insight into the co-evolution between plants and pathogens.

Wu Y, Zhou JM (2013) Receptor坼like kinases in plant innate immunity. J. Integr. Plant Biol. 55(12), 1271–1286.

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