%A Fan Xu, Li Huang, Junyao Wang, Caixia Ma, Yingqing Tan, Fanlong Wang, Yanhua Fan and Ming Luo %T Sphingolipid synthesis inhibitor fumonisin B1 causes verticillium wilt in cotton %0 Journal Article %D 2022 %J J Integr Plant Biol %R 10.1111/jipb.13241 %P 836-842 %V 64 %N 4 %U {https://www.jipb.net/CN/abstract/article_82242.shtml} %8 2022-04-01 %X

Verticillium wilt caused by Verticillium dahliae is a major disease of cotton. Acidic protein–lipopolysaccharide complexes are thought to be the toxins responsible for its symptoms. Here, we determined that the sphingolipid biosynthesis inhibitor fumonisin B1 (FB1) acts as a toxin and phenocopies the symptoms induced by V. dahliae. Knocking out genes required for FB1 biosynthesis reduced V. dahliae pathogenicity. Moreover, we showed that overexpression of a FB1 and V. dahliae both downregulated gene, GhIQD10, enhanced verticillium wilt resistance by promoting the expression of brassinosteroid and anti-pathogen genes. Our results provide a new strategy for preventing verticillium wilt in cotton.