Abstract: To further investigate the cyclopeptides of the Caryophyllaceae family, two new cyclopeptides, named Arenariphilin E (compound 1) and Arenariphilin F (compound 2), were obtained from Arenaria oreophila J. D. Hooker using some isolation methods, e. g. normal and reverse silica gel. By detailed spectroscopic analysis, such as FAB+-MS, 1D NMR, 2D NMR, the structures of Arenariphilin E (compound 1) and Arenariphilin F (compound 2) were determined as cyclo(Ile1-Gly-Val1-Ala-Leu-Ile3-Ile2-Val2-Pro) and cyclo(Pro2-Pro1-Gly2-Ile-Val-Leu-Gly1-Ala-Thr- Gly3), respectively.(Author for correspondence.Tel：0871-5223264；Fax：0871-5223261；E-mail：jzhou@mail.kib.ac.cn)

Key words: Arenaria oreophila, Arenariphilin E, Arenariphilin F, Caryophyllaceae, Cyclopeptide.