1. Bellagen Biotechnology Co. Ltd., Jinan 250000, China; 2. Institute of Advanced Biotechnology and School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China; 3. School of Life Sciences, Anhui Agricultural University, Hefei 230036, China; 4. Shandong Normal University, Jinan 250000, China †These authors contributed equally to this work. *Correspondence:Jian-Kang Zhu(zhujk@sustech.edu.cn);Hongtao Xie(xiehongtao@bellagen.cn, Dr. Xie is fully responsible for the distribution of all materials associated with this article in the manuscript)