Ethylene receptors at the ER: Potential hubs integrating hormone, redox, and Ca2+ signaling

doi:10.1111/jipb.70398

收稿日期:2026-07-05 修回日期:2026-09-01 接受日期:2026-09-03

Ethylene receptors at the ER: Potential hubs integrating hormone, redox, and Ca²⁺ signaling

Qianshen Zhang^1†, Yiping Wang^1†, Ruiqi Wang^1†, Jiale Zhang^1†, Savithramma P. Dinesh-Kumar², Xiaofeng Wang³ and Yongliang Zhang^1*

1. State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences, China Agricultural University, Beijing, 100193 China;
2. Department of Plant Biology and The Genome Center, College of Biological Sciences, University of California, Davis, 95616 California, USA;
3. School of Plant and Environmental Sciences, Virginia Tech, Virginia, 24061 USA
^†These authors contributed equally to this work.
^*Correspondence: Yongliang Zhang (cauzhangyl@cau.edu.cn)

Received:2026-07-05 Revised:2026-09-01 Accepted:2026-09-03
Supported by:
We would like to thank all the reviewers for the valuable suggestions on our manuscript. This work was supported by grants from the National Natural Science Foundation of China (32320103003), the Chinese Universities Scientific Fund (2026TC023), and the 2115 Talent Development Program of China Agricultural University.

摘要/Abstract

Abstract: Arabidopsis thaliana Ethylene Response 1 (ETR1) has long been viewed as a canonical hormone receptor initiating ethylene signaling at the endoplasmic reticulum (ER). Recent studies demonstrate that ETR1 also acts as an ER redox sensor, with disulfide-dependent dimerization controlling receptor conformation and activity. In parallel, subfamily I ethylene receptors, including ETR1, function as Ca²⁺-permeable channels, directly linking ethylene perception to rapid cytosolic Ca²⁺ elevation. Here, we summarize emerging evidence that redefines ETR1 as a multifunctional signaling hub connecting ethylene perception, redox regulation, and Ca²⁺ signaling. We present this integration as a working model and highlight unresolved questions concerning the mechanistic relationships among these functions. This framework provides a new perspective on how plants integrate ER homeostasis with hormone signaling to coordinate development and stress adaptation.

Key words: Ca²⁺ channel, ethylene receptor, ethylene response 1 (ETR1), evolution, multifunctional signaling hub, plant stress response, redox sensor

. [J]. J Integr Plant Biol, DOI: 10.1111/jipb.70398.

Qianshen Zhang, Yiping Wang, Ruiqi Wang, Jiale Zhang, Savithramma P. Dinesh-Kumar, Xiaofeng Wang, Yongliang Zhang. Ethylene receptors at the ER: Potential hubs integrating hormone, redox, and Ca²⁺ signaling[J]. J Integr Plant Biol, DOI: 10.1111/jipb.70398.

Ethylene receptors at the ER: Potential hubs integrating hormone, redox, and Ca²⁺ signaling

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