Abstract:

A new eremophilane sesquiterpenoid, along with two known ones, was isolated from the ethyl acetate soluble fraction of the aerial part of Coleus xanthanthus C. Y. Wu et Y. C. Huang. Their structures were elucidated as 4,5,11-trimethyl-8,9-seco-1(10),7(11)-eremophiladien-8,12-olid-9-oic acid (1), 2,9-dioxoeuryopsin (2) and 9-oxoeuryopsin (3) by spectral methods. The H-NMR and 13C-NMR data of compounds 1, 2 and 3 were unambiguously assigned on the basis of two-dimensional NMR spectroscopy.

黄鞘蕊花中的艾里莫芬烷型倍半萜
梅双喜¹ 张宏杰¹ 姜北¹ 李朝明¹ 吕扬² 龚宁波² 郑启泰²  孙汉董^1*

（1.  中国科学院昆明植物研究所，昆明650204；2. 中国医学科学院药物研究所，北京100050）

摘要：从黄鞘蕊花(Coleus xanthanthus C. Y. Wu et Y. C. Huang)的乙酸乙酯部分首次分离得到3个艾里莫芬烷型倍半萜类化合物(1～3),其结构由NMR波谱技术及单晶X衍射分析确定.其中,化合物1为新化合物, 命名为8,9_断裂_艾里莫芬_1(10),7(11)_二烯_8,12_内酯_9_酸.首次对化合物2 (2,9_二氧代优瑞坡森)和3 (9_氧代宽眼菊素)的1H-NMR和13C-NMR谱进行了全归属.

关键词： 黄鞘蕊花；艾里莫芬烷型倍半萜；8，9断裂-艾里莫芬-1（10），7（11）-二烯-8,12-内酯-9-酸，2,9-二氧代优瑞坡森；9-氧代宽眼菊素

Key words: Coleus xanthanthus, eremophilane sesquiterpenoids, 4,5,11-trimethyl-8,9-seco-1(10),7(11)-eremophiladien-8,12-olid-9-oic acid, 2,9-dioxoeuryopsin, 9-oxoeuryopsin