J Integr Plant Biol ›› 2023, Vol. 65 ›› Issue (8): 1846-1851.DOI: 10.1111/jipb.13493

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  • 收稿日期:2022-12-13 接受日期:2023-04-07 出版日期:2023-08-01 发布日期:2023-08-25

Tyrosylprotein sulfotransferase suppresses ABA signaling via sulfation of SnRK2.2/2.3/2.6

Jun Wang1,2†, Chunyan Wang1†, Tianrun Wang1†, Shizhong Zhang1, Kang Yan1, Guodong Yang1, Changai Wu1, Chengchao Zheng1* and Jinguang Huang1*   

  1. 1. State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian 271018, China;
    2. Department of Food Science and Engineering, Shandong Agriculture and Engineering University, Jinan 250100, China
    These authors contributed equally to this article.
    *Correspondence: Jinguang Huang (jghuang@sdau.edu.cn, Dr. Huang is fully responsible for the distributions of the materials associated with this article); Chengchao Zheng (cczheng@sdau.edu.cn)
  • Received:2022-12-13 Accepted:2023-04-07 Online:2023-08-01 Published:2023-08-25

Abstract: Phytohormone abscisic acid (ABA) plays vital roles in stress tolerance, while long-term overactivation of ABA signaling suppresses plant growth and development. However, the braking mechanism of ABA responses is not clear. Protein tyrosine sulfation catalyzed by tyrosylprotein sulfotransferase (TPST) is a critical post-translational modification. Through genetic screening, we identified a tpst mutant in Arabidopsis that was hypersensitive to ABA. In-depth analysis revealed that TPST could interact with and sulfate SnRK2.2/2.3/2.6, which accelerated their degradation and weakened the ABA signaling. Taken together, these findings uncovered a novel mechanism of desensitizing ABA responses via protein sulfation.

Key words: Arabidopsis, ABA signaling, tyrosylprotein sulfotransferase, sulfation, SnRK2.2/2.3/2.6

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