J Integr Plant Biol ›› 2022, Vol. 64 ›› Issue (4): 836-842.DOI: 10.1111/jipb.13241

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  • 收稿日期:2022-01-02 接受日期:2022-03-01 出版日期:2022-04-01 发布日期:2022-04-20

Sphingolipid synthesis inhibitor fumonisin B1 causes verticillium wilt in cotton

Fan Xu†, Li Huang†, Junyao Wang, Caixia Ma, Yingqing Tan, Fanlong Wang, Yanhua Fan and Ming Luo*   

  1. Key Laboratory of Biotechnology and Crop Quality Improvement of the Ministry of Agriculture, Biotechnology Research Center, Southwest University, Chongqing 400716, China

    †These authors contributed equally to this study
    *Correspondence: Ming Luo (luo0424@126.com)
  • Received:2022-01-02 Accepted:2022-03-01 Online:2022-04-01 Published:2022-04-20

Abstract:

Verticillium wilt caused by Verticillium dahliae is a major disease of cotton. Acidic protein–lipopolysaccharide complexes are thought to be the toxins responsible for its symptoms. Here, we determined that the sphingolipid biosynthesis inhibitor fumonisin B1 (FB1) acts as a toxin and phenocopies the symptoms induced by V. dahliae. Knocking out genes required for FB1 biosynthesis reduced V. dahliae pathogenicity. Moreover, we showed that overexpression of a FB1 and V. dahliae both downregulated gene, GhIQD10, enhanced verticillium wilt resistance by promoting the expression of brassinosteroid and anti-pathogen genes. Our results provide a new strategy for preventing verticillium wilt in cotton.

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