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School of Life Sciences,
Southwest University, Chongqing, 400715, China
E-mail: zhangyong916@swu.edu.cn
https://smkxxy.swu.edu.cn/info/1014/2396.htm
Area of expertise: Genome Editing, Non-coding RNA, Synthetic Biology
Selected Publications:
Zheng, X., Tang, X., Wu, Y., Zheng, X., Zhou, J., Han, Q., Tang, Y., Fu, X., Deng, J., Wang, Y., Wang, D., Zhang, S., Zhang, T., Qi, Y., and Zhang, Y. (2025). An efficient CRISPR-Cas12a-mediated MicroRNA knockout strategy in plants. Plant Biotechnol. J. 23: 128–140.
Fan, T., Cheng, Y., Wu, Y., Liu, S., Tang, X., He, Y., Liao, S., Zheng, X., Zhang, T., Qi, Y., and Zhang, Y. (2024). High performance TadA-8e derived cytosine and dual base editors with undetectable off-target effects in plants. Nat. Commun. 15: 5103.
He, Y., Liu, S., Chen, L., Pu, D., Zhong, Z., Xu, T., Ren, Q., Dong, C., Wang, Y., Wang, D., Zheng, X., Guo, F., Zhang, T., Qi, Y., and Zhang, Y. (2024). Versatile plant genome engineering using anti-CRISPR-Cas12a systems. Sci. China: Life Sci. 67: 2730–2745.
Zhang, R., Tang, X., He, Y., Li, Y., Wang, W., Wang, Y., Wang, D., Zheng, X., Qi, Y., and Zhang, Y. (2024). IsDge10 is a hypercompact TnpB nuclease that confers efficient genome editing in rice. Plant Commun. 5: 101068.
Zhou, J., Liu, G., Zhao, Y., Zhang, R., Tang, X., Li, L., Jia, X., Guo, Y., Wu, Y., Han, Y., Bao, Y., He, Y., Han, Q., Yang, H., Zheng, X., Qi, Y., Zhang, T., and Zhang, Y. (2023). An efficient CRISPR-Cas12a promoter editing system for crop improvement. Nat. Plants 9: 588–604.
Zhong, Z., Liu, G., Tang, Z., Xiang, S., Yang, L., Huang, L., He, Y., Fan, T., Liu, S., Zheng, X., Zhang, T., Qi, Y., Huang, J., and Zhang, Y. (2023).Efficient plant genome engineering using a probiotic sourced CRISPR-Cas9 system. Nat. Commun. 14: 6102.
Tang, X., and Zhang, Y. (2023). Beyond knockouts: Fine-tuning regulation of gene expression in plants with CRISPR-Cas-based promoter editing. New Phytol. 239: 868–874.
Ren, Q., Sretenovic, S., Liu, S., Tang, X., Huang, L., He, Y., Liu, L., Guo, Y., Zhong, Z., Liu, G., Cheng, Y., Zheng, X., Pan, C., Yin, D., Zhang, Y., Li, W., Qi, L., Li, C., Qi, Y., and Zhang, Y. (2021). PAM-less plant genome editing using a CRISPR-SpRY toolbox. Nat. Plants 7: 25–33.
Zhang, Y., Ren, Q., Tang, X., Liu, S., Malzahn, A. A., Zhou, J., Wang, J., Yin, D., Pan, C., Yuan, M., Huang, L., Yang, H., Zhao, Y., Fang, Q., Zheng, X., Tian, L., Cheng, Y., Le, Y., McCoy, B., Franklin, L., Selengut, J.D., Mount, S.M., Que, Q., Zhang, Y., and Qi, Y. (2021). Expanding the scope of plant genome engineering with Cas12a orthologs and highly multiplexable editing systems. Nat. Commun. 12: 1944.
Tang, X., Sretenovic, S., Ren, Q., Jia, X., Li, M., Fan, T., Yin, D., Xiang, S., Guo, Y., Liu, L., Zheng, X., Qi, Y., and Zhang, Y. (2020). Plant prime editors enable precise gene editing in rice cells. Mol. Plant 13: 667–670.
Ming, M., Ren, Q., Pan, C., He, Y., Zhang, Y., Liu, S., Zhong, Z., Wang, J., Malzahn, A. A., Wu, J., Zheng, X., Zhang, Y., and Qi, Y. (2020). CRISPR-Cas12b enables efficient plant genome engineering. Nat. Plants 6: 202–208.
Tang, X., Ren, Q., Yang, L., Bao, Y., Zhong, Z., He, Y., Liu, S., Qi, C., Liu, B., Wang, Y., Sretenovic, S., Zhang, Y., Zheng, X., Zhang, T., Qi, Y., and Zhang, Y. (2019). Single transcript unit CRISPR 2.0 systems for robust Cas9 and Cas12a mediated plant genome editing. Plant Biotechnol. J. 17: 1431–1445.
Zhong, Z., Sretenovic, S., Ren, Q., Yang, L., Bao, Y., Qi, C., Yuan, M., He, Y., Liu, S., Liu, X., Wang, J., Huang, L., Wang, Y., Baby, D., Wang, D., Zhang, T., Qi, Y., and Zhang, Y. (2019). Improving plant genome editing with high-fidelity xCas9 and non-canonical PAM-targeting Cas9-NG. Mol. Plant 12: 1027–1036.
Zhong, Z., Zhang, Y., You, Q., Tang, X., Ren, Q., Liu, S., Yang, L., Wang, Y., Liu, X., Liu, B., Zhang, T., Zheng, X., Le, Y., Zhang, Y., and Qi, Y. (2018). Plant genome editing using FnCpf1 and LbCpf1 nucleases at redefined and altered PAM sites. Mol. Plant 11: 999–1002.
Lowder, L. G., Zhou, J., Zhang, Y., Malzahn, A., Zhong, Z., Hsieh, T. F., Voytas, D. F., Zhang, Y., and Qi, Y. Robust transcriptional activation in plants using multiplexed CRISPR-Act2.0 and mTALE-Act systems. Mol. Plant 11: 245–256.
Tang, X., Lowder, L. G., Zhang, T., Malzahn, A. A., Zheng, X., Voytas, D. F., Zhong, Z., Chen, Y., Ren, Q., Li, Q., Kirkland, E. R., Zhang, Y., and Qi, Y. (2017). A CRISPR-Cpf1 system for efficient genome editing and transcriptional repression in plants. Nat. Plants 3: 17018.
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