Grapes have been a part of human civilization throughout our history. Cultivated grapes were domesticated from wild grapes and the cover illustrates the domestication process: wild grapes on the left contrast with cultivated grapes on the right, mitochondria symbolize the cytoplasmic component, a DNA double helix bridges genetic information exchange, and the nucleus within the grape fruits represents the nuclear genome. Together, these images highlight the continuous cytonuclear interactions that have shaped grape domestication. This cover features the study by Hou et al. (page: 2686–2703), who uncovered the potential role of cytoplasmic genomes in domestication, offering new insights into grape evolution and crop improvement.