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Professor, Head of DynaMo Center of Excellence,
Department of Plant and Environmental Sciences,
University of Copenhagen, Denmark
Thorvaldsensvej 40
Tel: +45 35 33 3342
E-mail: bah@plen.ku.dk
http://dynamo.ku.dk/people/halkier/
Area of expertise: Transport processes; specialized metabolism; synthetic biology; glucosinolates; biosynthesis; biochemistry
Selected Publications:
Wang, C., Dissing, M.M., Agerbirk, N., Crocoll, C., and Halkier, B.A. (2020). Characterization of Arabidopsis CYP79C1 and CYP79C2 by glucosinolate pathway engineering in Nicotiana benthamiana shows substrate specificity toward a range of aliphatic and aromatic amino acids. Front. Plant Sci. 11: 57.
Xu, D., Hunziker, P., Koroleva, O., Blennow, A., Crocoll, C., Schulz, A., Nour-Eldin, H.H., and Halkier, B.A. (2019). GTR-mediated radial import directs accumulation of defensive glucosinolates to sulfur-rich cells in the phloem cap of Arabidopsis inflorescence stem. Mol. Plant 12: 1474–1484.
Petersen, A., Crocoll, C., and Halkier, B.A. (2019). De novo production of benzyl glucosinolate in Escherichia coli. Metab. Eng. 54: 24–34.
Nintemann, S.J., Vik, D., Svozil, J., Bak, M., Baerenfaller, K., Burow, M., and Halkier, B.A. (2017). Unravelling protein-protein interaction networks linked to aliphatic and indole glucosinolate biosynthetic pathways in Arabidopsis. Front. Plant Sci. 8: 2028.
Burow, M., and Halkier, B.A. (2017). How does a plant orchestrate defense in time and space? Using glucosinolates in Arabidopsis as case study. Curr. Opin. Plant Boil. 38: 142–147.
Nour-Eldin, H.H., Madsen, S.R., Engelen, S., Jorgensen, M.E., Olsen, C.E., Andersen, J.S., Seynnaeve, D., Verhoye, T., Fulawka, R., Denolf, P., and Halkier, B. A. (2017). Reduction of antinutritional glucosinolates in Brassica oilseeds by mutation of genes encoding transporters. Nat. Biotechnol. 35: 377–382.
Xu, D., Hanschen, F.S., Witzel, K., Nintemann, S.J., Nour-Eldin, H.H., Schreiner, M., and Halkier, B.A. (2017). Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis. J. Exp. Bot. 68: 3205–3214.
Madsen, S.R., Nour-Eldin, H.H., and Halkier, B.A. (2016). Collection of apoplastic fluids from Arabidopsis thaliana leaves. Mol. Biol. 1405: 35-42.
Jorgensen, M.E., Nour-Eldin, H.H., and Halkier, B.A. (2015). Transport of defense compounds from source to sink: lessons learned from glucosinolates. Trends Plant Sci. 20: 508–514.
Madsen, S.R., Olsen, C.E., Nour-Eldin, H.H., and Halkier, B.A. (2014). Elucidating the role of transport processes in leaf glucosinolate distribution. Plant Physiol. 166: 1450–1462.
Andersen, T.G., Nour-Eldin, H.H., Fuller, V.L., Olsen, C.E., Burow, M., and Halkier, B.A. (2013). Integration of biosynthesis and long-distance transport establish organ-specific glucosinolate profiles in vegetative Arabidopsis. Plant Cell 25: 3133–45.
Nour-Eldin, H.H., and Halkier, B.A. (2013). The emerging field of transport engineering of plant specialized metabolites. Curr. Opin. Biotechnol. 24: 263-270.
Mikkelsen, M.D., Buron, L.D., Salomonsen, B., Olsen, C.E., Hansen, B.G., Mortensen, U.H., and Halkier, B.A. (2012). Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform. Metab. Eng. 14: 104–111.
Nour-Eldin, H.H., Andersen, T.G., Burow, M., Madsen, S.R., Jorgensen, M.E., Olsen, C.E., Dreyer, I., Hedrich, R., Geiger, D., and Halkier, B.A. (2012). NRT/PTR transporters are essential for translocation of glucosinolatedefence compounds to seeds. Nature 488: 531–534.
Geu-Flores, F., Møldrup, M.E., Böttcher, C., Olsen, C.E., Scheel, D., and Halkier, B.A. (2011). Cytosolic γ-glutamyl peptidases process glutathione conjugates in the biosynthesis of glucosinolates and camalexin in Arabidopsis. Plant Cell 23: 2456–2469.
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