Abstract: This paper deals with the effects of GA and NAA spraying on the embryogenesis of reciprocal crosses between Gossypium hirstum and G. arboreum. The main results are as follows: Spraying GA and NAA were no effects on the rates of pollination and fertilization. It is evident that sparying GA and NAA increased the percentage of embryonate ovules in the G. birsutum × G. arboreum, and the embryo size also increased evidently. In the G. arboreum × G. birsutum, spraying GA and NAA promoted the embryo differentiation remarkably and enabled the embryo differentiation approaching normally. Spraying GA and NAA are the effective methods to overcome the incompatibility in specific hybridization. It is due to the development of endosperm being promoted by spraying the exogenous phytohormone.