Please wait a minute...

J Integr Plant Biol, 56 (4): 334-342, Research Article
Recent advances in plant membrane-bound transcription factor research: Emphasis on intracellular movement
Pil Joon Seo1,2,3*
1Department of Bioactive Material Sciences, Chonbuk National University, Jeonju, Korea
2Research Center of Bioactive Materials, Chonbuk National University, Jeonju, Korea
3Department of Chemistry and Research Institute of Physics and Chemistry, Chonbuk National University, Jeonju, Korea
*Corresponding author E-mail:

Transcription factors constitute numerous signal transduction networks and play a central role in gene expression regulation. Recent studies have shown that a limited portion of transcription factors are anchored in the cellular membrane, storing as dormant forms. Upon exposure to environmental and developmental cues, these transcription factors are released from the membrane and translocated to the nucleus, where they regulate associated target genes. As this process skips both transcriptional and translational regulations, it guarantees prompt response to external and internal signals. Membrane-bound transcription factors (MTFs) undergo several unique steps that are not involved in the action of canonical nuclear transcription factors: proteolytic processing and intracellular movement. Recently, alternative splicing has also emerged as a mechanism to liberate MTFs from the cellular membranes, establishing an additional activation scheme independent of proteolytic processing. Multiple layers of MTF regulation add complexity to transcriptional regulatory scheme and ensure elaborate action of MTFs. In this review, we provide an overview of recent findings on MTFs in plants and highlight the molecular mechanisms underlying MTF liberation from cellular membranes with an emphasis on intracellular movement.

Seo PJ (2014) Recent advances in plant membrane‐bound transcription factor research: Emphasis on intracellular movement. J Integr Plant Biol 56: 334–342. doi: 10.1111/jipb.12139

Received: 30 July 2013      Published: 03 December 2013
© 2014 Institute of Botany, Chinese Academy of Sciences
This Article
   Full Text
   Full Text (PDF)
   Supporting information
   E-mail Link to this Article
   Export Citation for this Article
Citing Articles
   Cited By
Google Scholar
   Articles by Pil Joon Seo
   Articles by Pil Joon Seo
Editorial Office, Journal of Integrative Plant Biology, Institute of Botany, CAS
No. 20 Nanxincun, Xiangshan, Beijing 100093, China
Tel: +86 10 6283 6133 Fax: +86 10 8259 2636 E-mail:
Copyright © 2020 by the Institute of Botany, the Chinese Academy of Sciences
Online ISSN: 1744-7909 Print ISSN: 1672-9072 CN: 11-5067/Q