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J Integr Plant Biol
Receptor-like kinases MDS1 and MDS2 promote SUMM2-mediated immunity
Yanan Liu1,2, Xionghui Zhong2, Zhibin Zhang2, Jiameng Lan2, Xingchuan Huang1,2, Hainan Tian3, Xin Li2 and Yuelin Zhang2*
1Hunan Provincial Key Laboratory of Phytohormones and Growth Development, Hunan Agricultural University, Changsha 410000, China
2Department of Botany, University of British Columbia, 3529‐6270 University Blvd, Vancouver, British Columbia, V6T 1Z4, Canada
3Key Laboratory of Molecular Epigenetics of MOE, Northeast Normal University, Changchun 130000, China

*Correspondence:
Email: Yuelin Zhang (yuelin.zhang@ubc.ca)
doi: 10.1111/jipb.12978
Abstract

Disruption of the MEKK1‐MKK1/MKK2‐MPK4 kinase cascade leads to activation of immunity mediated by the nucleotide‐binding leucine‐rich repeat (NLR) immune receptor SUMM2, which monitors the phosphorylation status of CRCK3. Here we report that two receptor‐like kinases (RLKs), MDS1, and MDS2, function redundantly to promote SUMM2‐mediated immunity. Activation of SUMM2‐mediated immunity is dependent on MDS1, and to a less extent on MDS2. MDS1 associates with CRCK3 in planta and can phosphorylate CRCK3 in vitro , suggesting that it may target CRCK3 to positively regulate SUMM2‐mediated signaling. Our finding highlights a new defense mechanism where RLKs promote NLR‐mediated immunity.

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Received: 16 April 2020      Accepted:    Online on:04 June 2020
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