J Integr Plant Biol. ›› 2021, Vol. 63 ›› Issue (2): 283-296.DOI: 10.1111/jipb.13032

Special Issue: Plant-biotic interaction

• Invited Expert Review • Previous Articles     Next Articles

Diversity, structure and function of the coiled‐coil domains of plant NLR immune receptors

Junzhu Wang1,2, Meng Han1,2 and Yule Liu1,2*   

  1. 1MOE Key Laboratory of Bioinformatics, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    2Tsinghua‐Peking Center for Life Sciences, Beijing 100084, China

    *Correspondence: Yule Liu (yuleliu@mail.tsinghua.edu.cn)
  • Received:2020-08-01 Accepted:2020-11-03 Online:2020-11-18 Published:2021-02-01

Abstract: Plant nucleotide‐binding, leucine‐rich repeat receptors (NLRs) perceive pathogen avirulence effectors and activate defense responses. Nucleotide‐binding, leucine‐rich repeat receptors are classified into coiled‐coil (CC)‐containing and Toll/interleukin‐1 receptor (TIR)‐containing NLRs. Recent advances suggest that NLR CC domains often function in signaling activation, especially for induction of cell death. In this review, we outline our current understanding of NLR CC domains, including their diversity/classification and structure, their roles in cell death induction, disease resistance, and interaction with other proteins. Furthermore, we provide possible directions for future work.

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