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Institute of Advanced Biotechnology and School of Life Sciences,
Southern University of Science and Technology,
Shenzhen, China
E-mail: langzb@sustech.edu.cn
https://iab.sustech.edu.cn/Research-details-pid-35-typeid-2.html
Area of expertise: Epigenetics; DNA methylation; fruit ripening
Selected Publications:
Li, J.W., Yang, D.L., Huang, H., Zhang, G.P., He, L., Pang, J., Lozano-Duran, R., Lang, Z.B., and Zhu, J.K. (2020). Epigenetic memory marks determine epiallele stability at loci targeted by de novo DNA methylation. Nat. Plants 6: 661–674.
Liu, P., Nie, W.F., Xiong, X.S., Wang, Y.H., Jiang, Y.W., Huang, P., Lin, X.Q., Qin, G.C., Huang, H., Niu, Q.F., Du, J.M., Lang, Z.B., Lozano-Duran, R., and Zhu, J.K. (2021). A novel protein complex that regulates active DNA demethylation in Arabidopsis. J. Integr. Plant Biol. 63: 772–786.
Liu, R., and Lang, Z.B. (2020). The mechanism and function of active DNA demethylation in plants. J. Integr. Plant Biol. 62: 148–159.
Niu, Q.F., Wu, S.Q., Li, Y.S., Yang, X.X., Liu, P., Xu, Y.P., and Lang, Z.B. (2020). Expanding the scope of CRISPR/Cas9-mediated genome editing in plants using an xCas9 and Cas9-NG hybrid. J. Integr. Plant Biol. 62: 398–402.
Tang, D.G., Gallusci, P., and Lang, Z.B. (2020). Fruit development and epigenetic modifications. New Phytol. 228: 839–844.
Wang, X.G., Ren, M., Liu, D.N., Zhang, D.B., Zhang, C.J., Lang, Z.B., Macho, A.P., Zhang, M., and Zhu, J.K. (2020). Large-scale identification of expression quantitative trait loci in Arabidopsis reveals novel candidate regulators of immune responses and other processes. J. Integr. Plant Biol. 62: 1469–1483.
Huang, H., Liu, R.E., Niu, Q.F., Tang, K., Zhang, B., Zhang, H., Chen, K.S., Zhu, J.K., and Lang, Z.B. (2019). Global increase in DNA methylation during orange fruit development and ripening. Proc. Natl. Acad. Sci. USA 116: 1430–1436.
Huang, H., Liu, R., Niu, Q., Tang, K., Zhang, B., Zhang, H., Chen, K., Zhu, J.K., and Lang, Z. (2019). Global increase in DNA methylation during orange fruit development and ripening. Proc. Natl. Acad. Sci. USA 116:1430–1436.
Cheng, J., Niu, Q., Zhang, B., Chen, K., Yang, R., Zhu, J.K., Zhang, Y., and Lang, Z. (2018). Downregulation of RdDM during strawberry fruit ripening. Genome Biol. 19: 212
Zhang, H., Lang, Z., and Zhu, J.K. (2018). Dynamics and function of DNA methylation in plants. Nat. Rev. Mol. Cell Biol. 19: 489–506
Lang, Z., Wang, Y., Tang, K., Tang, D., Datsenka, T., Cheng, J., Zhang, Y., Handa, A.K., and Zhu, J.K. (2017). Critical roles of DNA demethylation in the activation of ripening-induced genes and inhibition of ripening-repressed genes in tomato fruit. Proc. Natl. Acad. Sci. USA 114: E4511–E4519
Tang, K., Lang, Z., Zhang, H., and Zhu, J.K. (2016). The DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications. Nat. Plants 2: 16169
Zhang, Q., Wang, D., Lang, Z., He, L., Yang, L., Zeng, L., Li, Y., Zhao, C., Huang, H., Zhang, H., Zhang, H., and Zhu, J.K. (2016). Methylation interactions in Arabidopsis hybrids require RNA-directed DNA methylation and are influenced by genetic variation. Proc. Natl. Acad. Sci. USA 113: E4248–56
Zhan, X., Yang, L., Wang, D., Zhu, J.K., and Lang, Z. (2016). De novo assembly and analysis of the transcriptome of Ocimum americanum var. pilosum under cold stress. BMC Genomics 17: 209
Wan, Y., Tang, K., Zhang, D., Xie, S., Zhu, X., Wang, Z., and Lang, Z. (2015) Transcriptome-wide high-throughput deep m(6)A-seq reveals unique differential m(6)A methylation patterns between three organs in Arabidopsis thaliana. Genome Biol. 16: 272
Lang, Z., Lei, M., Wang, X., Tang, K., Miki, D., Zhang, H., Mangrauthia, S.K., Liu, W., Nie, W., Ma, G., Yan, J., Duan, C.G., Hsu, C.C., Wang, C., Tao, W.A., Gong, Z., and Zhu, J.K. (2015). The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. Mol. Cell 57: 971–983
Zhan, X., Zhu, J.K., and Lang, Z. (2015). Increasing freezing tolerance: Kinase regulation of ICE1. Dev. Cell 32: 257–258
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