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Principle Investigator of the Research Group of Genome Editing in Crop Plants
Institute of Crop Sciences, Chinese Academy of Agricutlrual Sciences
12 Zhonguancun South Street
Beijing, 100081, China
Tel: 86-10-8210-5804
Fax: 86-10-8210-5804
E-mail: xialanqin@caas.cn
Website: http://ics.caas.cn/en/scientists/researchgroups/cfcgab/185582.htm
Area of expertise: Crop; Genome Editing; RNA Interference; Wheat Molecular Biology; Transgene; Plant-insect Interaction
Selected Publications:
Li, J.Y., Li, H.Y., Chen, J.L., Yan, L., and Xia, L.Q. (2020). Toward precision genome editing in crop plants. Mol. Plant 13: 811–813
Li, J.Y., Li, H.Y., Chen, J.L., Yan, L., and Xia, L.Q. (2020). Precise modifications of both exogenous and endogenous genes in rice by prime editing. Mol. Plant 13: 671–674.
Li, S., Zhang, Y., Xia, L.Q., and Qi,Y. (2020). CRISPR-Cas12a enables efficient biallelic gene targeting in rice. Plant Biotechnol. J. 18: 1351–1353.
Li, S.Y., Li, J.Y., He, Y.B., Xu, M.L., Zhang, J.H., Du, W.M., Zhao, Y.D., and Xia, L.Q. (2019). Precise gene replacement in rice by RNA transcript-templated homologous recombination. Nat. Biotechnol. 37: 445–450.
Sun, Y.W., Sparks, C., Jones, H.D., Riley, M., Francis, F., Du, W.M., and Xia, L.Q. (2019). Silencing an essential gene involved in infestation and digestion in grain aphid through plant-mediated RNA interference generates aphid-resistant wheat plants. Plant Biotechnol. J. 17: 852–854.
Li, J.Y., Luo, J.M., Xu, M.L., Li, S.Y., Zhang, J.H., Li, H.Y., Yan, L., Zhao, Y.D., and Xia, L.Q. (2019). Plant genome editing using xCas9 with expanded PAM compatibility. J. Genet. Genomics 46: 277–280.
Li, S.Y., Zhang, X., Wang, W., Guo, X., Wu, Z., Du, W., Zhao, Y.D., and Xia, L.Q. (2018). Expanding the scope of CRISPR/Cpf1-mediated genome editing in rice. Mol. Plant 11: 995–998.
Li, S.Y., Li, J.Y., Zhang, J.H., Du, W.M., Fu, J.D., Sutar, S., Zhao, Y.D., Xia, L.Q. (2018). Synthesis-dependent repair of Cpf1-induced double-strand DNA breaks enables targeted gene replacement in rice. J. Exp. Bot. 69: 4715–4721.
Li, J.Y., Zhang, X., Sun, Y., Zhang, J., Du, W., Guo, X., Li, S., Zhao, Y.D., and Xia, L.Q. (2018). Efficient allelic replacement in rice by gene editing: a case study of the NRT1.1B gene. J. Integr. Plant Biol. 60: 536–540.
Li, J.Y., Sun, Y., Du, J., Zhao, Y., and Xia, L.Q. (2017). Generation of targeted point mutations in rice by a modified CRISPR/Cas9 system. Mol. Plant 10: 526–529.
Sun, Y.W., Jiao, G., Liu, Z., Zhang, X., Li, J., Guo, X., Du, W., Du, J., Francis, F., Zhao Y., and Xia, L.Q. (2017). Generation of high-amylose rice through CRISPR/Cas9-mediated targeted mutagenesis of starch branching enzymes. Front Plant Sci. 8: 298.
Sun, Y.W., Zhang, X., Wu, C., He, Y., Ma, Y., Hou, H., Guo, X., Du, W., Zhao, Y., and Xia, L.Q. (2016). Engineering herbicide-resistant rice plants through CRISPR/Cas9-Mediated homologous recombination of acetolactate synthase. Mol. Plant 9: 628–631.
Wang, G.P., Yu, X.D., Sun, Y.W., Jones, H.D., and Xia, L.Q. (2016). Generation of marker- and/or backbone-free transgenic wheat plants via Agrobacterium-mediated transformation. Front Plant Sci. 7: 1324.
Yu, X.D., Liu, Z.C., Huang, S.L., Chen, Z.Q., Sun, Y., Duan, P.F., Ma, Y.Z., and Xia, L.Q. (2016). RNAi-mediated plant protection against aphids. Pest Manag. Sci. 72: 1090–1098.
Zhang, Y., Li, Z.X., Yu, X.D., Fan, J., Pickett, J.A., Jones, HD., Zhou, J.J., Birkett, M.A., Caulfield, J., Napier, J.A., Zhao, G.Y., Cheng, X.G., Shi, Y., Bruce, T., and Xia, L.Q. (2015). Molecular characterization of two isoforms of a farnesyl pyrophosphate synthase gene in wheat and their roles in sesquiterpene synthesis and inducible defence against aphid infestation. New Phytol. 206: 1101–1115.
Wang, G.P., Yu, X.D., Fan, J., Wang, C.S., and Xia, L.Q. (2015). Expressing an (E)-β-Farnesene synthase in the chloroplast of tobacco affects the preference of green peach aphid and its parasitoid. J. Integr. Plant Biol. 57: 770–782.
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