J Integr Plant Biol. ›› 2022, Vol. 64 ›› Issue (12): 2314-2326.DOI: 10.1111/jipb.13345

• Research Articles • Previous Articles     Next Articles

The chromatin remodeler BRAHMA recruits HISTONE DEACETYLASE6 to regulate root growth inhibition in response to phosphate starvation in Arabidopsis

Tao Li1,2†, Ruyue Zhang1,2†, Viswanathan Satheesh1, Peng Wang1, Guojie Ma1, Jianfei Guo1, Guo-Yong An3 and Mingguang Lei1,3*   

  1. 1 Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, China
    2 University of Chinese Academy of Sciences, Beijing 100049, China
    3 Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, Kaifeng 475004, China

    These authors contributed equally to this work.
    *Correspondence: Mingguang Lei (mglei@psc.ac.cn)
  • Received:2022-05-25 Accepted:2022-08-14 Online:2022-08-08 Published:2022-12-01

Abstract:

Plasticity in root system architecture (RSA) allows plants to adapt to changing nutritional status in the soil. Phosphorus availability is a major determinant of crop yield, and RSA remodeling is critical to increasing the efficiency of phosphorus acquisition. Although substantial progress has been made in understanding the signaling mechanism driving phosphate starvation responses in plants, whether and how epigenetic regulatory mechanisms contribute is poorly understood. Here, we report that the Switch defective/sucrose non-fermentable (SWI/SNF) ATPase BRAHMA (BRM) is involved in the local response to phosphate (Pi) starvation. The loss of BRM function induces iron (Fe) accumulation through increased LOW PHOSPHATE ROOT1 (LPR1) and LPR2 expression, reducing primary root length under Pi deficiency. We also demonstrate that BRM recruits the histone deacetylase (HDA) complex HDA6-HDC1 to facilitate histone H3 deacetylation at LPR loci, thereby negatively regulating local Pi deficiency responses. BRM is degraded under Pi deficiency conditions through the 26 S proteasome pathway, leading to increased histone H3 acetylation at the LPR loci. Collectively, our data suggest that the chromatin remodeler BRM, in concert with HDA6, negatively regulates Fe-dependent local Pi starvation responses by transcriptionally repressing the RSA-related genes LPR1 and LPR2 in Arabidopsis thaliana.

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