Abstract:

Two novel polyhydroxylated steroidal sapogenins, wattigenin B ((25R)-spirost-1β, 2β, 3β, 4β, 5β, 6β, 7α-heptol, 1) and wattigenin C ((25S)-spirost-1β, 2β, 3β, 4β, 5β, 7α-hexahydroxyl-6-one, 2), together with two known sapogenins, kitigenin (3) and convallagenin B (4), were isolated from the fresh rhizomes of Tupistra wattii Hook. f. The structures of the compounds were determined on the basis of spectroscopic analysis. The four sapogenins were evaluated for the cytotoxicities on the cancer cell line K562 and A2780a in vitro. Compounds 1-4 were obtained from the plant for the first time.

弯蕊开口箭中的多羟基甾体皂甙元
沈 平  王三龙  杨崇仁  蔡 兵 姚新生

（1.  沈阳药科大学，沈阳110016;2.  中国科学院昆明植物研究所，昆明650204；3.  北京生物医药研究所，北京100091）