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J Integr Plant Biol, 2003, 45 (5): 626-629, Research Article
Polyhydroxylated Steroidal Sapogenins from Tupistra wattii
SHEN Ping, WANG San-Long, YANG Chong-Ren, CAI Bing, YAO Xin-Sheng
doi:
Abstract

Two novel polyhydroxylated steroidal sapogenins, wattigenin B ((25R)-spirost-1β, 2β, 3β, 4β, 5β, 6β, 7α-heptol, 1) and wattigenin C ((25S)-spirost-1β, 2β, 3β, 4β, 5β, 7α-hexahydroxyl-6-one, 2), together with two known sapogenins, kitigenin (3) and convallagenin B (4), were isolated from the fresh rhizomes of Tupistra wattii Hook. f. The structures of the compounds were determined on the basis of spectroscopic analysis. The four sapogenins were evaluated for the cytotoxicities on the cancer cell line K562 and A2780a in vitro. Compounds 1-4 were obtained from the plant for the first time.

弯蕊开口箭中的多羟基甾体皂甙元
沈 平  王三龙  杨崇仁  蔡 兵 姚新生

(1.  沈阳药科大学,沈阳110016;2.  中国科学院昆明植物研究所,昆明650204;3.  北京生物医药研究所,北京100091)

摘要: 从弯蕊开口箭(Tupistrawattii Hook .f.)的新鲜根茎中分离出2个新的多羟基甾体皂甙元,分别命名为弯蕊皂甙元B (wattigeninB) (1)和弯蕊皂甙元C (wattigeninC) (2 ) ,同时分离到2个已知的甾体皂甙元——凯替皂甙元kitigenin (3)和铃兰皂甙元B (convallageninB) (4)。通过波谱解析鉴定了这4个皂甙元的结构,并测定了它们在体外对肿瘤细胞K5 6 2和A2 780a的细胞毒活性。化合物1~4为首次从该种植物中分离得到。
 
关键词: 弯蕊开口箭;甾体皂甙元;细胞毒活性
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