Integrative Biology Journals
JIPB

J Integr Plant Biol. ›› 2018, Vol. 60 ›› Issue (11): 1018-1022.DOI: 10.1111/jipb.12691  cstr: 32098.14.jipb.12691

• Letters to the Editor •     Next Articles

Essential role of NbNOG1 in ribosomal RNA processing

Jiangbo Guo1,2,3, Shaojie Han2, Jinping Zhao2, Cuihua Xin1, Xiyin Zheng2, Yule Liu2, Yan Wang2* and Feng Qu3*   

  1. 1School of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou 014010, China
    2MOE Key Laboratory of Bioinformatics, Center for Plant Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    3Department of Plant Pathology, the Ohio State University, Wooster, OH 44691, USA

    **    Correspondence:

    Email: Feng Qu (qu.28@osu.edu, Dr. Qu is fully responsible for the distribution of all materials associated with this article); Yan Wang (wangyansdts@163.com)
  • Received:2018-04-21 Accepted:2018-06-21 Online:2018-06-26 Published:2018-11-01

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Abstract:

Nucleolar GTP-binding protein 1 (NOG1) is a highly conserved GTPase first reported in Trypanosoma as required for ribosome biogenesis. We characterized NbNOG1, a Nicotiana benthamiana NOG1 ortholog sharing more than 45% amino acid identity with Trypanosoma, yeast, and human NOG1. N. benthamiana plants silenced for NbNOG1 were stunted and produced sterile flowers. NbNOG1 is functionally interchangeable with yeast NOG1 (ScNOG1), rescuing yeast lethality caused by loss of ScNOG1. Finally, NbNOG1 silencing caused over-accumulation of pre-rRNA processing intermediates, and concomitant loss of mature rRNAs. Collectively, these data support a role for NbNOG1 in ribosomal RNA processing.

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