J Integr Plant Biol. ›› 2006, Vol. 48 ›› Issue (2): -.

• Research Articles •    

New Cytotoxic Saponins from Lysimachia davurica Ledeb.

Jing-Kui Tian, Zhong-Mei Zou, Li-Zhen Xu and Shi-Lin Yang   

Abstract: To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I (compound 1) and E (compound 2) were isolated. Their chemical structures were elucidated as 3β,16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (compound 1) and 3β,16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (compound 2) on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells.(Author for correspondence.Tel (Fax): 0571 8827 3061; E-mail: tjk@zju.edu.cn)

Key words: davuricoside I and E, Lysimachia davurica, triterpene saponin.

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