Abstract: Swertia mussotii Fraeh (Family Gentianaceae) is a herb used as medicine for liver diseases in Tibetan. Its principal antihepatitisic constituents, oleanolic acid and mangiferin, have been reported. The present paper reports eight xanthones obtained from this plant. Their structures have been identified as 1,8-dihydroxy-3,5-dimethoxyxanthone Ⅰ, 1-hydroxy-3,5-dimethoxyxanthone Ⅱ, 1-hydroxy-3,7,8-trimethoxyxanthone Ⅲ, 8-hydroxy- 1,3,5-trimethoxyxanthone Ⅳ, 1,8-dihydroxy-3,7-dimethoxyxanthone Ⅴ, 1,7,8-trihydroxy- 3-methoxyxanthone Ⅵ, 1,7-dihydroxy-3,4,8-trimethoxyxanthone Ⅶ, and 1,3,8-trihydro- xy-5-methoxyxanthone Ⅷ. Of them, 1,7-dihydroxy-3,4,8-trimethoxyxanthone is a new natural product.