J Integr Plant Biol. ›› 1989, Vol. 31 ›› Issue (12): -.

• Research Articles •    

The Chemical Constituents from Cynanchum Komarovii Al. Ilinski

Fang Sheng-ding, Zhang Rui, Chen Yan, Xu Chuan-feng and Lu Shu-xi   

Abstract: Ten compounds were isolated from the roots and stems of Cynanchum komarovii Al. Iljinski. They were identified as 7-demethoxylophorine (Ⅰ), epi-alnusenol (Ⅱ), β-sitosterol (Ⅲ), triacontanolic acid (Ⅳ), sucrose (Ⅴ), desoxytylophorinin N-oxide (Ⅵ), apocynine (Ⅶ), paeonol (Ⅷ), β-sitosteryl-β-D-glucopyranoside (Ⅸ) and glucose (Ⅹ) by means of UV, IR, NMR, MS spectral analyses and through chemical methods. These compounds were first reported in this plant. One of them, Ⅵ is a new alkaloid. The bioassay results showed that the compounds Ⅰ, Ⅵ and reaction product Ⅺ exhibited cytotoxic effects to P-388 leukemia cell in vitro. Ⅺ is also a new compound.

Key words: Cynanchum komarovii Al. Iljinski, 7-demethoxylophorine, Desoxy- tylophorinin N-oxide, 7-demethoxylophorin N-oxide

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