J Integr Plant Biol. ›› 1989, Vol. 31 ›› Issue (5): -.

• Research Articles •    

The Chemical Constituents of Antitumor from Sabina vulgaris Ant

Fang Sheng-ding, Gu Yun-long, Yu Han-gang and Sayep Musadillin   

Abstract: Eleven known compounds, transcommunic acid (Ⅰ), cis-communic acid (Ⅱ), sandaracopimaric acid (Ⅲ), isocupressic acid (Ⅳ), sugiol (Ⅴ), 12-hydroxy-6, 7-seco- abieta-8, 11, 13-triene 6, 7-dial (Ⅵ), β-peltatin-A-methyl ether (Ⅶ), bergaptin (Ⅷ), β-sitosterol (Ⅹ), lignoceric acid (Ⅺ), cerotic acid(Ⅻ) and a new 3, 4-benzocumarins sabilactone (Ⅸ) were newly isolated from the bark of Sabina vulga ris Ant. (= Juniperus sabina L.). Their structures were determined from spectra data and chemical evidence. Compounds Ⅳ–Ⅹ were first isolated from this plant. The bioassay results showed that compounds Ⅰ–Ⅳ, Ⅵ andⅦ were shown to be cytotoxic effects for P-388 leukemia cell in vitro.

Key words: Sabina vulgaris Ant., 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial, β-peltatin-A-methyl ether, bergaptin, sabilactone.

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