Molecular regulation of the key specialized metabolism pathways in medicinal plants

doi:10.1111/jipb.13634

J Integr Plant Biol. ›› 2024, Vol. 66 ›› Issue (3): 510-531.DOI: 10.1111/jipb.13634

• Metabolism and Biochemistry • Previous Articles Next Articles

Molecular regulation of the key specialized metabolism pathways in medicinal plants

Min Shi^1†, Siwei Zhang^1†, Zizhen Zheng¹, Itay Maoz², Lei Zhang^3* and Guoyin Kai^1*

1. Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou 310053, China;
2. Department of Postharvest Science, Agricultural Research Organization, Volcani Center, Rishon, LeZion 7505101, Israel;
3. Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China
^†These authors contributed equally to this work.
^*Correspondences: Lei Zhang (zhanglei@smmu.edu.cn); Guoyin Kai (kaiguoyin@163.com, Dr. Kai is fully responsible for the distributions of all materials associated with this article)

Received:2023-12-27 Accepted:2024-02-10 Online:2024-03-05 Published:2024-03-01

Abstract

Abstract: The basis of modern pharmacology is the human ability to exploit the production of specialized metabolites from medical plants, for example, terpenoids, alkaloids, and phenolic acids. However, in most cases, the availability of these valuable compounds is limited by cellular or organelle barriers or spatio-temporal accumulation patterns within different plant tissues. Transcription factors (TFs) regulate biosynthesis of these specialized metabolites by tightly controlling the expression of biosynthetic genes. Cutting-edge technologies and/or combining multiple strategies and approaches have been applied to elucidate the role of TFs. In this review, we focus on recent progress in the transcription regulation mechanism of representative high-value products and describe the transcriptional regulatory network, and future perspectives are discussed, which will help develop high-yield plant resources.

Key words: biosynthesis, medicinal plants, omics, secondary metabolism, transcription factors

Min Shi, Siwei Zhang, Zizhen Zheng, Itay Maoz, Lei Zhang and Guoyin Kai. Molecular regulation of the key specialized metabolism pathways in medicinal plants[J]. J Integr Plant Biol., 2024, 66(3): 510-531.

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Molecular regulation of the key specialized metabolism pathways in medicinal plants

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