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Department of Plant and Microbial Biology
North Carolina State University
Raleigh, NC, 27695
USA
Tel.: 1-9195152129, Fax: 1-9195153436, Cell Phone: 1-9198408482
E-mail: dxie@ncsu.edu
https://sites.google.com/view/deyuxielaboratory
Area of expertise: Plant secondary metabolism, flavonoids, proanthocyanidins, anthocyanins, artemisinin, terpenoids, nicotine, alkaloids
Selected Publications:
Xie, D.Y., Sharma, S.B., Paiva, N.L., Ferreira, D., and Dixon, R.A. (2003). Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis. Science 299: 396-399.
Xie, D.Y., Sharma, S.B., Wright, E., Wang, Z.Y., and Dixon, R.A. (2006). Metabolic engineering of proanthocyanidins through co-expression of anthocyanidin reductase and the PAP1 MYB transcription factor. Plant J. 45: 895-907.
Shi, M.Z., and Xie, D.Y. (2011). Engineering of red cells of Arabidopsis thaliana and comparative genome-wide gene expression analysis of red cells vs. wild-type cells. Planta 233: 787-805.
Alejos-Gonzalez, F., Qu, G., Zhou, L.L., Saravitz, C.H., Shurtleff, J.L., and Xie, D.Y. (2011). Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants. Planta 234: 685-697.
Ma, D.M., Wang, Z., Wang, L., Alejos-Gonzales, F., Sun, M.A., and Xie, D.Y. (2015). A genome-wide scenario of terpene pathways in self-pollinated Artemisia annua. Mol. Plant 8: 1580–1598.
Xie, D.Y., Ma, D.M., Judd, R., and Loray Jones, A. (2016) Artemisinin biosynthesis in Artemisia annua and metabolic engineering: Questions, challenges, and perspectives. Phytochem. Rev. 15: 1093-1114.
Ma, D., Li, G., Alejos-Gonzalez, F., Zhu, Y., Xue, Z., Wang, A., Zhang, H., Li, X., Ye, H., Wang, H., Liu, B., and Xie, D.Y. (2017). Overexpression of a type I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase. Plant J. 91: 466–479.
Judd, R., Bagley, M.C., Li, M., Zhu, Y., Lei, C., Yuzuak, S., Ekelöf, M., Pu, G., Zhao, X., Muddiman, D.C., and Xie, D.Y. (2019). Artemisinin biosynthesis in non-glandular trichome cells of Artemisia annua, Mol. Plant 12: 704-714.
Zhu, Y., and Xie, D.Y. (2020). Docking characterization and in vitro inhibitory activity of flavan-3-ols and dimeric proanthocyanidins against the main protease activity of SARS-Cov-2. Front. Plant Sci. 11: 1884.
Li, M., He, X., La Hovary, C., Zhu, Y, Dong, Y., Liu, S., Xing, H., Liu, Y., Jie, Y., Ma, D., Yuzuak, S., and Xie, D.Y. (2022). A de novo regulation design shows an effectiveness in altering plant secondary metabolism. J. Adv. Res. 37: 43-60.
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