J Integr Plant Biol. ›› 2005, Vol. 47 ›› Issue (7): -.DOI: 10.1111/j.1744-7909.2005.00042.x

• Research Articles •    

Components of Stem Barks of Winchia calophylla A. DC. And Their Bronchodilator Activities

Wei-Ming ZHU, Hong-Ping HE, Li-Ming FAN, Yue-Mao SHEN, Jun ZHOU and Xiao-Jiang HAO   

Abstract: The Dai medicinal plant Winchia calophylla A. DC. (Apocynaceae) has efficacy as an anti-cough and anti-asthmatic medication. In order to investigate its relative bioactive components, we studied the chemical constituents of this plant. Using repeated column chromatography, 28 compounds, including loganin, six phenolic compounds, 17 indole alkaloids, three pyridine alkaloids, and a quinoline alkaloid, were isolated from the stem barks of W. calophylla. Loganin, paeonol, N (4)-methyl akuammicine, and cantleyine exhibited a moderate relaxation effect on isolated smooth muscles of guinea-pig tracheal spirals and lung strips and may be the bioactive components responsible for the bronchodilation produced by W. calophylla.

Key words: alkaloid, Apocynaceae, bronchodilatation, Winchia calophylla.

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