J Integr Plant Biol. ›› 2005, Vol. 47 ›› Issue (12): 1412-1417.DOI: 10.1111/j.1744-7909.2005.00218.x

• Research Articles • Previous Articles     Next Articles

Seek and Ye Shall [eventually] Find: The End of the Search for the Auxin Receptor

Lawrence HOBBIE   

Abstract: The mechanism by which the plant hormone auxin regulates gene expression has been shown to involve regulated degradation, through the ubiquitin-proteasome pathway, of transcriptional repressor proteins. However, the key first component in this pathway, the receptor that binds auxin and initiates auxin signaling, has remained a mystery. Two recent papers identify the F-box protein TIR1, part of the complex that attaches ubiquitin to its targets, as an auxin receptor. This breakthrough reveals a new mode of signal transduction and lays the groundwork for a more complete understanding of auxin physiology.

Key words: auxin, auxin receptor, SCF complex, signal transduction, ubiquitin.

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