J Integr Plant Biol. ›› 2008, Vol. 50 ›› Issue (5): 589-592.DOI: 10.1111/j.1744-7909.2008.00661.x

• Stress & Phytochemistry • Previous Articles     Next Articles

Two New Triterpenoid Saponins from Gymnema sylvestre

Xu-Min Zhu, Ping Xie, Ying-Tong Di, Shu-Lin Peng, Li-Sheng Ding and Ming-Kui Wang   

Abstract: Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structures of the new compounds were elucidated as 16 β-hydroxyl olean-12-en-3-O-[β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl]-28-O-β-D-glucopyranoside(1) and 16 β,21 β,28-trihydroxyl-olean-12-ene-3-O-glucoronopyranoside (2). The EtOH/H2O extracts of this plant were shown to be able to inhibit glucose absorption in rats.

Key words: Gymnema sylvestre, gymnemoside-W1 and W2, triterpenoid Saponin.

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