J Integr Plant Biol. ›› 2013, Vol. 55 ›› Issue (12): 1212-1223.DOI: 10.1111/jipb.12080

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Structure-function Aspects of Extracellular Leucine-rich Repeat-containing Cell Surface Receptors in Plants

Zhao Zhang1 and Bart P.H.J. Thomma1,2*   

  1. 1Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands
    2Centre for BioSystems Genomics, P.O. Box 98, 6700 AB Wageningen, The Netherlands
  • Received:2013-03-24 Accepted:2013-05-23 Published:2013-12-01
  • About author:*Corresponding author Tel: +31 317 484536; Fax: +31 317 483412 E-mail: bart.thomma@wur.nl


Plants exploit several types of cell surface receptors for perception of extracellular signals, of which the extracellular leucine-rich repeat (eLRR)-containing receptors form the major class. Although the function of most plant eLRR receptors remains unclear, an increasing number of these receptors are shown to play roles in innate immunity and a wide variety of developmental processes. Recent efforts using domain swaps, gene shuffling analyses, site-directed mutagenesis, interaction studies, and crystallographic analyses resulted in the current knowledge on ligand binding and the mechanism of activation of plant eLRR receptors. This review provides an overview of eLRR receptor research, specifically summarizing the recent understanding of interactions among plant eLRR receptors, their co-receptors and corresponding ligands. The functions of distinct eLRR receptor domains, and their role in structure, ligand perception and multimeric complex formation are discussed.

Zhang Z, Thomma BPHJ (2013) Structure‐function aspects of extracellular leucine‐rich repeat‐containing cell surface receptors in plants. J. Integr. Plant Biol. 55(12), 1212–1223.

Key words: eLRR, receptor-like kinase (RLK), receptor-like protein (RLP), pathogen-associated molecular pattern (PAMP), effector, peptide ligand, brassinosteroid CLE peptide

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