J Integr Plant Biol. ›› 2013, Vol. 55 ›› Issue (12): 1198-1211.DOI: 10.1111/jipb.12081

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Ligand Perception, Activation, and Early Signaling of Plant Steroid Receptor Brassinosteroid Insensitive 1

Jianjun Jiang, Chi Zhang and Xuelu Wang*   

  1. State Key Laboratory of Genetic Engineering and Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China
  • Received:2013-02-01 Accepted:2013-05-23 Published:2013-12-01
  • About author:*Corresponding author: Tel/Fax: +86 21 6510 2247 E-mail: xueluw@gmail.com

Abstract:

Leucine-rich repeat receptor-like kinases (LRR-RLKs) belong to a large group of cell surface proteins involved in many aspects of plant development and environmental responses in both monocots and dicots. Brassinosteroid insensitive 1 (BRI1), a member of the LRR X subfamily, was first identified through several forward genetic screenings for mutants insensitive to brassinosteroids (BRs), which are a class of plant-specific steroid hormones. Since its identification, BRI1 and its homologs had been proved as receptors perceiving BRs and initiating BR signaling. The co-receptor BRI1-associated kinase 1 and its homologs, and other BRI1 interacting proteins such as its inhibitor BRI1 kinase inhibitor 1 (BKI1) were identified by genetic and biochemical approaches. The detailed mechanisms of BR perception by BRI1 and the activation of BRI1 receptor complex have also been elucidated. Moreover, several mechanisms for termination of the activated BRI1 signaling were also discovered. In this review, we will focus on the recent advances on the mechanism of BRI1 phosphorylation and activation, the regulation of its receptor complex, the structure basis of BRI1 ectodomain and BR recognition, its direct substrates, and the termination of the activated BRI1 receptor complex.

Jiang J, Zhang C, Wang X (2013) Ligand perception, activation, and early signaling of plant steroid receptor brassinosteroid insensitive 1. J. Integr. Plant Biol. 55(12), 1198–1211.

Key words: Brassinosteroid insensitive 1-associated kinase 1, brassinosteroid insensitive 1 kinase inhibitor 1, brassinosteroids, brassinosteroid insensitive 1, phosphorylation, receptor-like kinase, recognition signaling

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