J Integr Plant Biol. ›› 2021, Vol. 63 ›› Issue (7): 1382-1396.DOI: 10.1111/jipb.13082

Special Issue: Development Plant-biotic interaction

• Plant-biotic Interactions • Previous Articles    

The Phytophthora effector Avh241 interacts with host NDR1-like proteins to manipulate plant immunity

Bo Yang1,2, Sen Yang1,2, Baodian Guo1,2, Yuyin Wang1,2, Wenyue Zheng1,2, Mengjun Tian1,2, Kaixin Dai1,2, Zehan Liu1,2, Haonan Wang1,2, Zhenchuan Ma1,2, Yan Wang1,2, Wenwu Ye1,2, Suomeng Dong1,2 and Yuanchao Wang1,2*   

  1. 1 Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    2 The Key Laboratory of Plant Immunity, Nanjing Agricultural University, Nanjing 210095, China

    *Correspondence: Yuanchao Wang (wangyc@njau.edu.cn)
  • Received:2020-11-16 Accepted:2021-02-12 Online:2021-02-15 Published:2021-07-01

Abstract: Plant pathogens rely on effector proteins to suppress host innate immune responses and facilitate colonization. Although the Phytophthora sojae RxLR effector Avh241 promotes Phytophthora infection, the molecular basis of Avh241 virulence remains poorly understood. Here we identified non-race specific disease resistance 1 (NDR1)-like proteins, the critical components in plant effector-triggered immunity (ETI) responses, as host targets of Avh241. Avh241 interacts with NDR1 in the plasma membrane and suppresses NDR1-participated ETI responses. Silencing of GmNDR1s increases the susceptibility of soybean to P. sojae infection, and overexpression of GmNDR1s reduces infection, which supports its positive role in plant immunity against P. sojae. Furthermore, we demonstrate that GmNDR1 interacts with itself, and Avh241 probably disrupts the self-association of GmNDR1. These data highlight an effective counter-defense mechanism by which a Phytophthora effector suppresses plant immune responses, likely by disturbing the function of NDR1 during infection.

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