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J Integr Plant Biol, 2003, 45 (11): 1383-1386, Research Article
ent-Kaurene Diterpenoids from Isodon adenanthus
XIANG Wei, HAN Quan-Bin, LI Sheng-Hong, NA Zhi, SUN Han-Dong*
doi:
Abstract

Three new ent -kaurene diterpenoids, adenanthins N, O and P (1–3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid, 9,16-dioxo-10,12,14-octadeca-trienoic acid (8), were isolated from Isodon adenanthus (Diels) Kudo. The structure of compound 4 was revised accordingly. Compound 1 showed significant cytotoxic activity against K562 cells with IC50 = 0.45 µg/mL.

腺花香茶菜中的对映-贝壳杉烯类二萜化合物
项 伟 韩全斌 黎胜红 纳 智 孙汉董
(中国科学院昆明植物研究所植物化学与西部植物资源国家重点实验室, 昆明 650204)


摘要: 从昆明产腺花香茶菜(Isodon adenanthus (Diels) Kudo)的地上部分分离到8个化合物,通过波谱分析鉴定,化合物1-3为新的对映-贝壳杉烯类二萜化合物,命名为腺花香茶菜素N、O和P;4个已知二萜为白叶香茶菜戊素(4)、 无毛狭叶香茶菜素C (5)、 腺花香茶菜甲素(6)和白叶香茶菜乙素(7), 同时得到一个高度不饱和脂肪酸9,16-二羰基-10,12,14-三烯-十八碳酸(8)。根据ROESY波谱,对化合物4的结构进行了修正。化合物1对K562细胞显示出明显的细胞毒活性(IC50 = 0.45 μg/mL)。
关键词: 腺花香茶菜;唇形科;对映-贝壳杉烯类二萜化合物;腺花香茶菜素N、O和P

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