J Integr Plant Biol. ›› 2008, Vol. 50 ›› Issue (6): 699-702.DOI: 10.1111/j.1744-7909.2008.00672.x

• Stress & Phytochemistry • Previous Articles     Next Articles

Two New neo-Clerodane Diterpenoids from Scutellaria barbata

Sheng-Jun Dai, Li Shen and Yan Ren   

Abstract: Two new neo-clerodane diterpenoids, 6,7-dibenzoyloxybarbatin C (1, named barbatin D) and 6-(2-acetoxy-3-methylbutanoloxy)-7-(2-carbonyl-3-methylbutanoyloxy) barbatin C (2, named barbatin E) were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1–2 showed cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in the range of 3.5–6.7 μM.

Key words: barbatin D, barbatin E, cytotoxic activity, neo-clerodane diterpenoid, Scutellaria barbata.

Editorial Office, Journal of Integrative Plant Biology, Institute of Botany, CAS
No. 20 Nanxincun, Xiangshan, Beijing 100093, China
Tel: +86 10 6283 6133 Fax: +86 10 8259 2636 E-mail: jipb@ibcas.ac.cn
Copyright © 2022 by the Institute of Botany, the Chinese Academy of Sciences
Online ISSN: 1744-7909 Print ISSN: 1672-9072 CN: 11-5067/Q