Integrative Biology Journals
JIPB

J Integr Plant Biol. ›› 2022, Vol. 64 ›› Issue (11): 2097-2110.DOI: 10.1111/jipb.13350

• Cell and Developmental Biology • Previous Articles     Next Articles

COP1 SUPPRESSOR 6 represses the PIF4 and PIF5 action to promote light-inhibited hypocotyl growth

Hongxia Lan1†, Yueqin Heng1†, Jian Li1†, Mengdi Zhang1, Yeting Bian2, Li Chu2, Yan Jiang1, Xuncheng Wang3, Dongqing Xu2* and Xing Wang Deng1,4*   

  1. 1. Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, Department of Biology, Institute of Plant and Food Sciences, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China
    2. State Key Laboratory of Crop Genetics and Germplasm Enhancement, National Center for Soybean Improvement, College of Agriculture, Nanjing Agricultural University, Nanjing 210095, China
    3. Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China, Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China
    4. State Key Laboratory of Protein and Plant Gene Research, Peking‐Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences and School of Life Sciences, Peking University, Beijing 100871, China

    † These authors contributed equally to this work.
    *Correspondences: Dongqing Xu (dongqingxu@njau.edu.cn, Dr. Xu is fully responsible for the distributions of all materials associated with this article); Xing Wang Deng (deng@pku.edu.cn)
  • Received:2022-05-29 Accepted:2022-08-26 Online:2022-09-26 Published:2022-11-01

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Abstract:

Light signaling precisely controls photomorphogenic development in plants. PHYTOCHROME INTERACTING FACTOR 4 and 5 (PIF4 and PIF5) play critical roles in the regulation of this developmental process. In this study, we report CONSTITUTIVELY PHOTOMORPHOGENIC 1 SUPPRESSOR 6 (CSU6) functions as a key regulator of light signaling. Loss of CSU6 function largely rescues the cop1-6 constitutively photomorphogenic phenotype. CSU6 promotes hypocotyl growth in the dark, but inhibits hypocotyl elongation in the light. CSU6 not only associates with the promoter regions of PIF4 and PIF5 to inhibit their expression in the morning, but also directly interacts with both PIF4 and PIF5 to repress their transcriptional activation activity. CSU6 negatively controls a group of PIF4- and PIF5-regulated gene expressions. Mutations in PIF4 and/or PIF5 are epistatic to the loss of CSU6, suggesting that CSU6 acts upstream of PIF4 and PIF5. Taken together, CSU6 promotes light-inhibited hypocotyl elongation by negatively regulating PIF4 and PIF5 transcription and biochemical activity.

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