J Integr Plant Biol. ›› 1992, Vol. 34 ›› Issue (6): -.

• Research Articles •    

Study on the Triterpenoids of Tripterygium regeli

Shen Jian-hua and Zhou Bing-nan   

Abstract: Ten triterpenoids were isolated from the ethanol extract of the roots of Tripteryglum regeli collected from Jilin Province, north-eastern China. They were identified as wilforlide A(1), wilforlide B(2), regelide (3) 3β-hydroxy-olean-ll,13(18)-diene (4), orthosphenic acid (5), salaspermic acid (6), 3-epikatonic acid(7), maytenfolic acid (8), 3β-acetyl-oleanolic acid (9), and celastrol (19), by spectroscopic analyses and chemical correlations. Compound 3—10 were isolated from T. regeli for the first time, among them regelide 3 was a new comound and its structure was elucidated to be 3-keto-22α-hydroxy-olean-ll,13(18)-dien-29-oic acid(29, 22α)-lactone. 3-epikatonic acid(7)showed obvious spermicidal effect, while cealstrol (10)revealed significant immunosuppressive activity.

Key words: Tripterygium regeli, Triterpenoid, Regelide

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