J Integr Plant Biol. ›› 1978, Vol. 20 ›› Issue (2): -.

• Research Articles •    

A Study on the Antitumor Plant Cephalotaxus oliveri Mast.

Zhang Feng-xian, Wang Zhu-hao, Pan Wen-dou, Li Yu-jing, Mai Lang-tian, Sun Jian-quan and Ma Guang-en   

Abstract: Three alkaloids: harringtonine, cephalotaxine and schelhammera alkaloid B were isolated from Cephalotaxus oliveri Mast. which is distributed in Guangdong Sheng. The inhibiting effect of harringtonine for sarcoma 180 in mice was 42.3% at a dosage of 1 mg/kg. It showed high activity against the acute nonlymphoblastic leukemia in clinical experiments. A pretty high yield of 1.3/10000 antileukemic ingredient harring- tonine was extracted from the plant and the resources of C. oliveri Mast. in China are abundant, so that this plant is a good material to produce harringtonine.

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