Abstract:

A new saikosaponin was isolated from Bupleurum chinense DC., and its structure was identified as 3β，16α，23，28，30-pentahydroxy-olean-11,13(18)-dien-3-O-β-D-glucopyranosyl(1→6)-［α-L-rhamnopyranosyl (1→4)］-β-D-glucopyranoside on the basis of chemical and spectral evidence, named as saikosaponin q-1. In addition, two known saikosaponins, 3″-O-acetyl-saikosaponin d and 3″-O-acetyl-saikosaponin b2, were also isolated and identified from this plant for the first time.

新化合物柴胡皂甙q-1 的结构鉴定
梁鸿¹韩紫岩¹ 赵玉英^1*王邠¹ 崔育新¹杨文修² 余奕²

（1. 北京大学药学院，北京100083；2.  南开大学生物物理与技术系，天津300071）

摘要：从北柴胡（Bupheurum chinense DC.）根的醇提液的正丁醇部分分离得到３个化合物，分别鉴定为柴胡皂甙q-1（１）、３″－Ｏ－乙酰柴胡皂甙d(2)和３″－Ｏ－乙酰柴胡皂甙b2(3).化合物１为新化合物，用化学和波谱法确定其结构为３β，１６α，２３，２８，３０－五羟基－齐墩果－１１，１３（１８）－二烯－３－Ｏ－β－Ｄ吡喃葡萄糖（１→６）－[α-L-吡喃鼠李糖基（１→４）]－β－Ｄ－吡喃葡萄糖甙。化合物２和３为首次从北柴胡中分离得到。
关键词： 北柴胡；柴胡皂甙q-1

Key words: Bupleurum chinense , saikosaponin q-1