Abstract: Three new 2,2-dimethylehroman derivatives named leptin A ( Ⅰ ), leptin B ( Ⅱ ), and leptin C ( Ⅲ ), along with a known compound--isoevodionol ( Ⅳ ), have been isolated from the aerial parts of Evodia lepta (Spreng.) Merr. Based on the spectroscopic analysis and chemical evidence, compounds Ⅰ , Ⅱ , Ⅲ were elucidated as cis-3,4,5-trihydroxy-6-acetyl-7-methoxy-2,2-dimethylehroman,trans-3,4, 5-trihydroxy-6-aeetyl-7-methoxy-2, 2-dimethylehroman and 3,5-dihy- droxy-4-ethoxy-6-aeetyl-7-methoxy-2,2- dimethylehroman, respectively.

Key words: Evodia lepta, leptin A, leptin B, leptin C