Abstract:

Four diterpenoids, including a new ent kaurane diterpene (1), were isolated from the rhizome of Aralia fargesii Franch. On the basis of chemical and spectral evidence (IR, EI-MS, HREI-MS,1H-NMR,13C-NMR and HMQC), the structure of compound 1 was established to be 17-acetoxy-16α-ent-kauran-19-oic acid. The other three known compounds were identified as ent-pimara-8(14),15-dien-19-oic acid (2), 16α –hydroxy-(－)-kauran-19-oic acid (3) and 16α-17-dihydroxy-ent-kauran –9-oic acid (4). The three known diterpenoids were obtained from this plant for the first time.

龙眼独活中的一个新二萜成分

张聿梅  杨峻山

(中国协和医科大学、中国医学科学院药用植物研究所,北京,100094)

从四川产楤木属(Aralia)草本植物龙眼独活(Aralia fargesii Franch.)根茎的石油醚提取部分分离得到4个二萜化合物,根据理化性质测定和各种光谱(IR、EI-MS、HREI-MS、1H-NMR、13C-NMR和HMQC)数据分析,它们的结构分别鉴定为17-acetoxy-16α-ent-kauran-19-oic acid (1), ent-pimara-8(14),15-dien-19-oic acid (2), 16α-hydroxy-(-)-kauran-19-oic acid (3) 和16α-17-dihydroxy-ent-kauran-19-oic acid (4).化合物1为新化合物,3为首次从该属植物中分离得到,2～4为首次从龙眼独活中分离得到.

关键词 龙眼独活 二萜

*通讯作者

Key words: Aralia fargesii, diterpenoid, 17-acetoxy-16α-ent-kauran-19-oic acid