J Integr Plant Biol. ›› 2019, Vol. 61 ›› Issue (9): 974-980.DOI: 10.1111/jipb.12728

Special Issue: Abiotic stress

• Letters to the Editor • Previous Articles     Next Articles

Endoplasmic reticulum stress-induced accumulation of VAMP721/722 requires CALRETICULIN 1 and CALRETICULIN 2 in Arabidopsis

Soohong Kim1, Yunjin Choi1, Chian Kwon1,* and Hye Sup Yun2,*   

  1. 1Department of Molecular Biology, Dankook University, Cheonan 31116, Korea
    2Department of Biological Sciences, Konkuk University, Seoul 05029, Korea

    Email: Hye Sup Yun (hsyun@konkuk.ac.kr); Chian Kwon (chiank@dankook.ac.kr).Drs. Yun and Kwon are fully responsible for the distribution of all materials associated with this article.
  • Received:2018-06-14 Accepted:2018-09-27 Online:2018-10-02 Published:2019-09-01


Excessive demand for translation and protein folding in the endoplasmic reticulum (ER) can cause ER stress in plants. Here, we show that CALRETICULIN 1 (CRT1) and CRT2 are critical components in the accumulation of VESICLE‐ASSOCIATED MEMBRANE PROTEIN 721 (VAMP721) and VAMP722 during ER stress responses. We show that CRT2 interacts with VAMP722 and that CRT1/2 post‐translationally maintain elevated VAMP721/722 levels under ER stress. The greater growth inhibition in VAMP721/722‐deficient plants, induced by tunicamycin, suggests that plants under ER stress maintain physiological homeostasis, at least in part, by regulating VAMP721/722 levels, as VAMP721/722 are known to participate in various biological processes.

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