J Integr Plant Biol. ›› 2023, Vol. 65 ›› Issue (2): 371-380.DOI: 10.1111/jipb.13346

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Protein ubiquitination in plant peroxisomes

Delara Akhter1,2,3†, Yuchan Zhang1,2†, Jianping Hu4,5* and Ronghui Pan1,2*   

  1. 1. State Key Laboratory of Rice Biology, Zhejiang Provincial Key Laboratory of Crop Genetic Resources, College of Agriculture and Biotechnology & ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310058/311200, China;
    2. Zhejiang Laboratory, Hangzhou 311121, China;
    3. Department of Genetics and Plant Breeding, Sylhet Agricultural University, Sylhet 3100, Bangladesh;
    4. Department of Energy Plant Research Laboratory and Plant Biology Department, Michigan State University, East Lansing, Michigan, USA;
    5. Department of Plant Biology, Michigan State University, East Lansing, Michigan, USA
    These authors contributed equally to this work.
    *Correspondences: Jianping Hu (huji@msu.edu); Ronghui Pan (panr@zju.edu.cn, Dr. Pan is fully responsible for the distributions of all materials associated with this article)
  • Received:2022-06-30 Accepted:2022-08-11 Online:2022-08-17 Published:2023-02-01

Abstract: Protein ubiquitination regulates diverse cellular processes in eukaryotic organisms, from growth and development to stress response. Proteins subjected to ubiquitination can be found in virtually all subcellular locations and organelles, including peroxisomes, single-membrane and highly dynamic organelles ubiquitous in eukaryotes. Peroxisomes contain metabolic functions essential to plants and animals such as lipid catabolism, detoxification of reactive oxygen species (ROS), biosynthesis of vital hormones and cofactors, and photorespiration. Plant peroxisomes possess a complex proteome with functions varying among different tissue types and developmental stages, and during plant response to distinct environmental cues. However, how these diverse functions are regulated at the post-translational level is poorly understood, especially in plants. In this review, we summarized current knowledge of the involvement of protein ubiquitination in peroxisome protein import, remodeling, pexophagy, and metabolism, focusing on plants, and referencing discoveries from other eukaryotic systems when relevant. Based on previous ubiquitinomics studies, we compiled a list of 56 ubiquitinated Arabidopsis peroxisomal proteins whose functions are associated with all the major plant peroxisomal metabolic pathways. This discovery suggests a broad impact of protein ubiquitination on plant peroxisome functions, therefore substantiating the need to investigate this significant regulatory mechanism in peroxisomes at more depths.

Key words: peroxins, peroxisome, peroxisome biogenesis, peroxisome metabolism, pexophagy, ubiquitination

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